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In this review, we provide an overview of the different described roles of placental EVs in various aspects of normal pregnancy, from placenta establishment to maternal immune tolerance towards the fetus and protection against viral infections. In the second part, we present selected examples of pathological pregnancies in which placental EVs are involved, such as gestational diabetes mellitus, pre-eclampsia, and congenital infections. Since the abundance and\/or composition of placental EVs is deregulated in maternal serum during pathological pregnancies, this makes them interesting candidates as non-invasive biomarkers for gestational diseases and opens a wide field of translational perspectives.<\/jats:p>","DOI":"10.1042\/bst20220734","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T14:25:19Z","timestamp":1670595919000},"page":"1785-1795","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Placental extracellular vesicles in maternal-fetal communication during pregnancy"],"prefix":"10.1042","volume":"50","author":[{"given":"Charl\u00e8ne","family":"Martin","sequence":"first","affiliation":[{"name":"1Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM, CNRS, UPS, Universit\u00e9 de Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Bergamelli","sequence":"additional","affiliation":[{"name":"2Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile E.","family":"Malnou","sequence":"additional","affiliation":[{"name":"1Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), INSERM, CNRS, UPS, Universit\u00e9 de Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-2241","authenticated-orcid":false,"given":"Gisela","family":"D'Angelo","sequence":"additional","affiliation":[{"name":"3Institut Curie, CNRS UMR144, Structure et Compartiments Membranaires, Universit\u00e9 Paris Sciences et Lettres, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"2022121614383905100_BST-2022-0734CC1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","year":"2018","journal-title":"Nat. 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