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Current knowledge, including genetic analyses of gain- and loss-of-function mutants, highlights the importance of APPs in various physiological functions. Notably, APPs consist of multiple extracellular and intracellular protein-binding regions\/domains. Protein\u2013protein interactions are crucial for many cellular processes. In past decades, many APPs interactors have been identified which assist the revelation of the putative roles of APPs. Importantly, some of these interactors have been shown to influence several APPs-mediated neuronal processes which are found defective in AD and other neurodegenerative disorders. Studying APPs\u2013interactor complexes would not only advance our understanding of the physiological roles of APPs but also provide further insights into the association of these processes to neurodegeneration, which may lead to the development of novel therapies. In this mini-review, we summarize the roles of APPs\u2013interactor complexes in neurodevelopmental processes including neurogenesis, neurite outgrowth, axonal guidance and synaptogenesis.<\/jats:p>","DOI":"10.1042\/bst20221527","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T06:37:48Z","timestamp":1688107068000},"page":"1647-1659","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Amyloid precursor protein and its interacting proteins in neurodevelopment"],"prefix":"10.1042","volume":"51","author":[{"given":"Dennis Dik-Long","family":"Chau","sequence":"first","affiliation":[{"name":"School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Lok-Haang","family":"Ng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhai","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0193-1152","authenticated-orcid":false,"given":"Kwok-Fai","family":"Lau","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,6,30]]},"reference":[{"key":"2023102408350568000_BST-2022-1527CC1","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1007\/s00018-009-0020-8","article-title":"Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors","volume":"66","year":"2009","journal-title":"Cell. 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