{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:29:27Z","timestamp":1792146567158,"version":"4.4.0"},"reference-count":124,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,6,28]]},"abstract":"<jats:p>Nesprins (nuclear envelope spectrin repeat proteins) are multi-isomeric scaffolding proteins. Giant nesprin-1 and -2 localise to the outer nuclear membrane, interact with SUN (Sad1p\/UNC-84) domain-containing proteins at the inner nuclear membrane to form the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex, which, in association with lamin A\/C and emerin, mechanically couples the nucleus to the cytoskeleton. Despite ubiquitous expression of nesprin giant isoforms, pathogenic mutations in nesprin-1 and -2 are associated with tissue-specific disorders, particularly related to striated muscle such as dilated cardiomyopathy and Emery\u2013Dreifuss muscular dystrophy. Recent evidence suggests this muscle-specificity might be attributable in part, to the small muscle specific isoform, nesprin-1\u03b12, which has a novel role in striated muscle function. Our current understanding of muscle-specific functions of nesprin-1 and its isoforms will be summarised in this review to provide insight into potential pathological mechanisms of nesprin-related muscle disease and may inform potential targets of therapeutic modulation.<\/jats:p>","DOI":"10.1042\/bst20221541","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T07:34:19Z","timestamp":1683876859000},"page":"1331-1345","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Nesprin-1: novel regulator of striated muscle nuclear positioning and mechanotransduction"],"prefix":"10.1042","volume":"51","author":[{"given":"Shanelle","family":"De Silva","sequence":"first","affiliation":[{"name":"1King's College London British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, London SE5 9NU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijuan","family":"Fan","sequence":"additional","affiliation":[{"name":"1King's College London British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, London SE5 9NU, U.K."},{"name":"2Clinical Laboratory, Tianjin Third Central Hospital, Tianjin 300170, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqiang","family":"Kang","sequence":"additional","affiliation":[{"name":"1King's College London British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, London SE5 9NU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Shanahan","sequence":"additional","affiliation":[{"name":"1King's College London British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, London SE5 9NU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4000-3957","authenticated-orcid":false,"given":"Qiuping","family":"Zhang","sequence":"additional","affiliation":[{"name":"1King's College London British Heart Foundation Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, London SE5 9NU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"2023062811303590600_BST-2022-1541C1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1083\/jcb.200509124","article-title":"Coupling of the nucleus and cytoplasm: role of the LINC complex","volume":"172","year":"2006","journal-title":"J. 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