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While enzymes from these distinct families have seemingly opposing activities, certain E3\u2013DUB pairings can also synergize to regulate vital cellular processes like gene expression, autophagy, innate immunity, and cell proliferation. In this review, we highlight recent studies describing Ub ligase-DUB interactions and focus on their relationships.<\/jats:p>","DOI":"10.1042\/bst20230454","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:34:05Z","timestamp":1709109245000},"page":"241-267","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Friend or foe? 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