{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:22:39Z","timestamp":1792077759900,"version":"4.4.0"},"reference-count":83,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,24]]},"abstract":"<jats:p>The RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a \u2018writer\u2019 complex catalysing m6A modification. Conversely, FTO and ALKBH5 function as demethylases, rendering m6A dynamic. Key to understanding the functional significance of m6A is its \u2018reader' proteins, exemplified by YTH-domain-containing proteins (YTHDFs) canonical reader and insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) non-canonical reader. These proteins play a crucial role in determining RNA stability: YTHDFs mainly promote mRNA degradation through different cytoplasmic pathways, whereas IGF2BPs function to maintain mRNA stability. Additionally, YTHDC1 functions within the nucleus to degrade or protect certain m6A-containing RNAs, and other non-canonical readers also contribute to RNA stability regulation. Notably, m6A regulates retrotransposon LINE1 RNA stability and\/or transcription via multiple mechanisms. However, conflicting observations underscore the complexities underlying m6A's regulation of RNA stability depending upon the RNA sequence\/structure context, developmental stage, and\/or cellular environment. Understanding the interplay between m6A and other RNA regulatory elements is pivotal in deciphering the multifaceted roles m6A plays in RNA stability regulation and broader cellular biology.<\/jats:p>","DOI":"10.1042\/bst20230574","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:36:46Z","timestamp":1713339406000},"page":"707-717","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["RNA m6A modification, signals for degradation or stabilisation?"],"prefix":"10.1042","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-426X","authenticated-orcid":false,"given":"Guifeng","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Oxford, Oxford OX1 3QU, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"2024042414514694500_BST-2023-0574CC1","doi-asserted-by":"publisher","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","year":"1974","journal-title":"Proc. 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