{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:08:34Z","timestamp":1784365714346,"version":"3.55.0"},"reference-count":138,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,2,28]]},"abstract":"<jats:p>The underlying cause of Spinal Muscular Atrophy (SMA) is in the reduction of survival motor neuron (SMN) protein levels due to mutations in the SMN1 gene. The specific effects of SMN protein loss and the resulting pathological alterations are not fully understood. Given the crucial roles of the SMN protein in snRNP biogenesis and its interactions with ribosomes and translation-related proteins and mRNAs, a decrease in SMN levels below a specific threshold in SMA is expected to affect translational control of gene expression. This review covers both direct and indirect SMN interactions across various translation-related cellular compartments and processes, spanning from ribosome biogenesis to local translation and beyond. Additionally, it aims to outline deficiencies and alterations in translation observed in SMA models and patients, while also discussing the implications of the relationship between SMN protein and the translation machinery within the context of current and future therapies.<\/jats:p>","DOI":"10.1042\/bst20231116","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T11:02:35Z","timestamp":1708686155000},"page":"465-479","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The SMN-ribosome interplay: a new opportunity for Spinal Muscular Atrophy therapies"],"prefix":"10.1042","volume":"52","author":[{"given":"Gaurav","family":"Sharma","sequence":"first","affiliation":[{"name":"Institute of Biophysics, CNR, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Paganin","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, CNR, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Lauria","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, CNR, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Perenthaler","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, CNR, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6755-285X","authenticated-orcid":false,"given":"Gabriella","family":"Viero","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, CNR, Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"2024022816402191300_BST-2023-1116CC1","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1038\/s41580-018-0034-x","article-title":"Translation deregulation","volume":"19","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC2","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/s41556-020-00577-7","article-title":"SMN-primed ribosomes modulate the translation of transcripts related to spinal muscular atrophy","volume":"22","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC3","doi-asserted-by":"publisher","first-page":"6307","DOI":"10.1073\/pnas.96.11.6307","article-title":"A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy","volume":"96","year":"1999","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2024022816402191300_BST-2023-1116CC4","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","year":"1995","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC5","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S0092-8674(00)80368-2","article-title":"The SMN\u2013SIP1 complex has an essential role in spliceosomal snRNP biogenesis","volume":"90","year":"1997","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC6","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1016\/S0960-9822(01)00592-9","article-title":"Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln","volume":"11","year":"2001","journal-title":"Curr. Biol."},{"key":"2024022816402191300_BST-2023-1116CC7","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/S0960-9822(01)00316-5","article-title":"The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1","volume":"11","year":"2001","journal-title":"Curr. Biol."},{"key":"2024022816402191300_BST-2023-1116CC8","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0092-8674(00)81632-3","article-title":"A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing","volume":"95","year":"1998","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC9","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/978-3-319-89689-2_6","article-title":"RNP assembly defects in spinal muscular atrophy","volume":"2018","year":"2018","journal-title":"Adv. Neurobiol."},{"key":"2024022816402191300_BST-2023-1116CC10","doi-asserted-by":"publisher","first-page":"e202101145","DOI":"10.26508\/LSA.202101145","article-title":"SMN-deficient cells exhibit increased ribosomal DNA damage","volume":"5","year":"2022","journal-title":"Life Sci. Alliance"},{"key":"2024022816402191300_BST-2023-1116CC11","doi-asserted-by":"publisher","first-page":"e1000773","DOI":"10.1371\/journal.pgen.1000773","article-title":"Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy","volume":"5","year":"2009","journal-title":"PLoS Genet."},{"key":"2024022816402191300_BST-2023-1116CC12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1046\/j.1460-9568.1999.00428.x","article-title":"Subcellular distribution of survival motor neuron (SMN) protein: possible involvement in nucleocytoplasmic and dendritic transport","volume":"11","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC13","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1093\/hmg\/dds474","article-title":"A novel function for the survival motoneuron protein as a translational regulator","volume":"22","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2478\/v10134-010-0027-6","article-title":"SMN complexes of nucleus and cytoplasm: a proteomic study for SMA therapy","volume":"1","year":"2010","journal-title":"Transl. Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC15","doi-asserted-by":"publisher","first-page":"10337","DOI":"10.1073\/pnas.1104928108","article-title":"Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits","volume":"108","year":"2011","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2024022816402191300_BST-2023-1116CC16","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.1523\/JNEUROSCI.3631-10.2011","article-title":"The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons","volume":"31","year":"2011","journal-title":"J. Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC17","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.celrep.2017.10.010","article-title":"In vivo translatome profiling in spinal muscular atrophy reveals a role for SMN protein in ribosome biology","volume":"21","year":"2017","journal-title":"Cell Rep."},{"key":"2024022816402191300_BST-2023-1116CC18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s40478-020-01101-6","article-title":"Mitochondrial defects in the respiratory complex I contribute to impaired translational initiation via ROS and energy homeostasis in SMA motor neurons","volume":"8","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"2024022816402191300_BST-2023-1116CC19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S40035-022-00304-2\/FIGURES\/10","article-title":"Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus\u2013response in spinal muscular atrophy","volume":"11","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"2024022816402191300_BST-2023-1116CC20","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.tins.2020.11.009","article-title":"Spinal muscular atrophy: in the challenge lies a solution","volume":"44","year":"2021","journal-title":"Trends Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC21","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrn2670","article-title":"Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?","volume":"10","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC22","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1093\/hmg\/ddy195","article-title":"Temporal and tissue-specific variability of SMN protein levels in mouse models of spinal muscular atrophy","volume":"27","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.bbagrm.2016.12.008","article-title":"Diverse role of survival motor neuron protein","volume":"1860","year":"2017","journal-title":"Biochim.t Biophys. Acta"},{"key":"2024022816402191300_BST-2023-1116CC24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-76174-3","article-title":"SMN protein promotes membrane compartmentalization of ribosomal protein S6 transcript in human fibroblasts","volume":"10","year":"2020","journal-title":"Sci. Rep."},{"key":"2024022816402191300_BST-2023-1116CC25","doi-asserted-by":"publisher","first-page":"e202201429","DOI":"10.26508\/lsa.202201429","article-title":"SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members","volume":"6","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"2024022816402191300_BST-2023-1116CC26","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3390\/biom8040106","article-title":"2\u2032-O-Methylation of ribosomal RNA: towards an epitranscriptomic control of translation?","volume":"8","year":"2018","journal-title":"Biomolecules"},{"key":"2024022816402191300_BST-2023-1116CC27","doi-asserted-by":"publisher","first-page":"38645","DOI":"10.1074\/jbc.M106161200","article-title":"Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2024022816402191300_BST-2023-1116CC28","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/hmg\/11.9.1017","article-title":"A novel association of the SMN protein with two major non-ribosomal nucleolar proteins and its implication in spinal muscular atrophy","volume":"11","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC29","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1091\/mbc.10.1.77","article-title":"Association of nonribosomal nucleolar proteins in ribonucleoprotein complexes during interphase and mitosis","volume":"10","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"2024022816402191300_BST-2023-1116CC30","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1039\/c6mb00740f","article-title":"Crosstalk between the nucleolus and the DNA damage response","volume":"13","year":"2017","journal-title":"Mol. Biosyst."},{"key":"2024022816402191300_BST-2023-1116CC31","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/s41594-021-00669-4","article-title":"Regulation of translation by site-specific ribosomal RNA methylation","volume":"28","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2024022816402191300_BST-2023-1116CC32","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/j.devcel.2023.06.007","article-title":"Ribosomal RNA 2\u2032-O-methylation dynamics impact cell fate decisions","volume":"58","year":"2023","journal-title":"Dev. Cell"},{"key":"2024022816402191300_BST-2023-1116CC33","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1242\/jcs.176750","article-title":"SMN affects membrane remodelling and anchoring of the protein synthesis machinery","volume":"129","year":"2016","journal-title":"J. Cell Sci."},{"key":"2024022816402191300_BST-2023-1116CC34","doi-asserted-by":"publisher","first-page":"rs8","DOI":"10.1126\/scisignal.2001699","article-title":"A directed protein interaction network for investigating intracellular signal transduction","volume":"4","year":"2011","journal-title":"Sci. Signal"},{"key":"2024022816402191300_BST-2023-1116CC35","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1021\/pr900884g","article-title":"The SMN interactome includes Myb-binding protein 1a","volume":"9","year":"2010","journal-title":"J. Proteome Res."},{"key":"2024022816402191300_BST-2023-1116CC36","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cell.2015.06.043","article-title":"The BioPlex network: a systematic exploration of the human interactome","volume":"162","year":"2015","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC37","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.1021\/pr1005263","article-title":"Valproate and bone loss: ITRAQ proteomics show that valproate reduces collagens and osteonectin in SMA cells","volume":"9","year":"2010","journal-title":"J. Proteome Res."},{"key":"2024022816402191300_BST-2023-1116CC38","doi-asserted-by":"publisher","first-page":"8335","DOI":"10.1093\/nar\/gkw702","article-title":"The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation","volume":"44","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2024022816402191300_BST-2023-1116CC39","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1016\/j.celrep.2017.11.008","article-title":"Cellular and molecular anatomy of the human neuromuscular junction","volume":"21","year":"2017","journal-title":"Cell Rep."},{"key":"2024022816402191300_BST-2023-1116CC40","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.cell.2017.05.022","article-title":"The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity","volume":"169","year":"2017","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC41","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/S0955-0674(02)00332-0","article-title":"The SMN complex, an assemblyosome of ribonucleoproteins","volume":"14","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC42","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1021\/pr9006987","article-title":"Identification of novel interacting protein partners of SMN using tandem affinity purification","volume":"9","year":"2010","journal-title":"J. Proteome Res."},{"key":"2024022816402191300_BST-2023-1116CC43","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/nature12104","article-title":"Structures of the human and Drosophila 80S ribosome","volume":"497","year":"2013","journal-title":"Nature"},{"key":"2024022816402191300_BST-2023-1116CC44","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1261\/rna.040204.113","article-title":"Genome-wide identification of mRNAs associated with the protein SMN whose depletion decreases their axonal localization","volume":"19","year":"2013","journal-title":"RNA"},{"key":"2024022816402191300_BST-2023-1116CC45","doi-asserted-by":"publisher","first-page":"10983","DOI":"10.1093\/nar\/gky770","article-title":"High-affinity RNA targets of the Survival Motor Neuron protein reveal diverse preferences for sequence and structural motifs","volume":"46","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2024022816402191300_BST-2023-1116CC46","doi-asserted-by":"publisher","first-page":"35375","DOI":"10.1021\/acsomega.1c04688","article-title":"Spinal muscular atrophy patient iPSC-derived motor neurons display altered proteomes at early stages of differentiation","volume":"6","year":"2021","journal-title":"ACS Omega"},{"key":"2024022816402191300_BST-2023-1116CC47","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1021\/pr500492j","article-title":"Label-free quantitative proteomic profiling identifies disruption of ubiquitin homeostasis as a key driver of Schwann cell defects in spinal muscular atrophy","volume":"13","year":"2014","journal-title":"J. Proteome Res."},{"key":"2024022816402191300_BST-2023-1116CC48","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3389\/fncel.2015.00506","article-title":"Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development","volume":"9","year":"2016","journal-title":"Front. Cell Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC49","doi-asserted-by":"publisher","first-page":"2624","DOI":"10.3390\/cells11172624","article-title":"The proteome signatures of fibroblasts from patients with severe, intermediate and mild spinal muscular atrophy show limited overlap","volume":"11","year":"2022","journal-title":"Cells"},{"key":"2024022816402191300_BST-2023-1116CC50","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1093\/hmg\/ddq340","article-title":"SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy","volume":"19","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC51","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/gm498","article-title":"Label-free proteomics identifies Calreticulin and GRP75\/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy","volume":"5","year":"2013","journal-title":"Genome Med."},{"key":"2024022816402191300_BST-2023-1116CC52","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1021\/acs.jproteome.9b00159","article-title":"Pathologic alterations in the proteome of synaptosomes from a mouse model of spinal muscular atrophy","volume":"18","year":"2019","journal-title":"J. Proteome Res."},{"key":"2024022816402191300_BST-2023-1116CC53","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1172\/JCI71318","article-title":"Dysregulation of ubiquitin homeostasis and \u03b2-catenin signaling promote spinal muscular atrophy","volume":"124","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2024022816402191300_BST-2023-1116CC54","doi-asserted-by":"publisher","first-page":"5742","DOI":"10.1093\/nar\/gku177","article-title":"Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation","volume":"42","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2024022816402191300_BST-2023-1116CC55","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.molcel.2006.05.036","article-title":"The Gemin5 protein of the SMN complex identifies snRNAs","volume":"23","year":"2006","journal-title":"Mol. Cell"},{"key":"2024022816402191300_BST-2023-1116CC56","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nsmb.1584","article-title":"Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains","volume":"16","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2024022816402191300_BST-2023-1116CC57","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1007\/s00018-022-04519-4","article-title":"Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs","volume":"79","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"2024022816402191300_BST-2023-1116CC58","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1038\/s41467-021-22627-w","article-title":"Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder","volume":"12","year":"2021","journal-title":"Nat. Commun."},{"key":"2024022816402191300_BST-2023-1116CC59","doi-asserted-by":"publisher","first-page":"e01257","DOI":"10.7554\/eLife.01257","article-title":"Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments","volume":"3","year":"2014","journal-title":"Elife"},{"key":"2024022816402191300_BST-2023-1116CC60","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.1093\/hmg\/ddaa146","article-title":"Pre-natal manifestation of systemic developmental abnormalities in spinal muscular atrophy","volume":"29","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC61","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1534\/genetics.113.153197","article-title":"Ribosome biogenesis in the yeast Saccharomyces cerevisiae","volume":"195","year":"2013","journal-title":"Genetics"},{"key":"2024022816402191300_BST-2023-1116CC62","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/wrna.1263","article-title":"Cotranscriptional events in eukaryotic ribosome synthesis","volume":"6","year":"2015","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"2024022816402191300_BST-2023-1116CC63","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/s41594-019-0263-5","article-title":"Local translation in neurons: visualization and function","volume":"26","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2024022816402191300_BST-2023-1116CC64","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.cell.2009.01.042","article-title":"Regulation of translation initiation in eukaryotes: mechanisms and biological targets","volume":"136","year":"2009","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC65","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.nmd.2016.06.004","article-title":"Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy","volume":"26","year":"2016","journal-title":"Neuromuscul. Disord."},{"key":"2024022816402191300_BST-2023-1116CC66","doi-asserted-by":"crossref","first-page":"894917","DOI":"10.1117\/12.2038462","volume-title":"Proc. SPIE 8949, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI","author":"Brown","year":"2014"},{"key":"2024022816402191300_BST-2023-1116CC67","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1126\/science.1197236","article-title":"Video-rate molecular imaging in vivo with stimulated Raman scattering","volume":"330","year":"2010","journal-title":"Sci."},{"key":"2024022816402191300_BST-2023-1116CC68","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/1471-2164-13-220","article-title":"Widespread uncoupling between transcriptome and translatome variations after a stimulus in mammalian cells","volume":"13","year":"2012","journal-title":"BMC Genomics"},{"key":"2024022816402191300_BST-2023-1116CC69","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","year":"2009","journal-title":"Science"},{"key":"2024022816402191300_BST-2023-1116CC70","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1080\/14789450.2017.1345631","article-title":"Advances in understanding the role of disease-associated proteins in spinal muscular atrophy","volume":"14","year":"2017","journal-title":"Expert. Rev. Proteomics"},{"key":"2024022816402191300_BST-2023-1116CC71","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1093\/hmg\/ddad121","article-title":"AAV9-mediated SMN gene therapy rescues cardiac desmin but not lamin A\/C and elastin dysregulation in Smn 2B\/\u2212 spinal muscular atrophy mice","volume":"32","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC72","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1093\/hmg\/ddz195","article-title":"Lamin A\/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy","volume":"28","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC73","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3390\/brainsci11030296","article-title":"Cerebrospinal fluid parameters in antisense oligonucleotide-treated adult 5q-spinal muscular atrophy patients","volume":"11","year":"2021","journal-title":"Brain Sci."},{"key":"2024022816402191300_BST-2023-1116CC74","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.nbd.2017.08.004","article-title":"Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: role of Cajal bodies and the nucleolus","volume":"108","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"2024022816402191300_BST-2023-1116CC75","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/nar\/gku1291Fnorthern","article-title":"The association of late-acting snoRNPs with human pre-ribosomal complexes requires the RNA helicase DDX21","volume":"43","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2024022816402191300_BST-2023-1116CC76","doi-asserted-by":"publisher","first-page":"e1010392","DOI":"10.1371\/journal.pgen.1010392","article-title":"Single-cell RNA sequencing reveals dysregulation of spinal cord cell types in a severe spinal muscular atrophy mouse model","volume":"18","year":"2022","journal-title":"PLoS Genet."},{"key":"2024022816402191300_BST-2023-1116CC77","doi-asserted-by":"publisher","first-page":"5948","DOI":"10.1093\/nar\/gkad259","article-title":"Diverse targets of SMN2-directed splicing-modulating small molecule therapeutics for spinal muscular atrophy","volume":"51","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2024022816402191300_BST-2023-1116CC78","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/s41593-021-00913-6","article-title":"A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies","volume":"24","year":"2021","journal-title":"Nat. Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC79","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s40478-015-0231-1","article-title":"Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn (2b\/-) mouse model of spinal muscular atrophy","volume":"3","year":"2015","journal-title":"Acta Neuropathol. Commun."},{"key":"2024022816402191300_BST-2023-1116CC80","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1016\/j.celrep.2019.11.025","article-title":"On-site ribosome remodeling by locally synthesized ribosomal proteins in axons","volume":"29","year":"2019","journal-title":"Cell Rep."},{"key":"2024022816402191300_BST-2023-1116CC81","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1128\/mcb.00879-12","article-title":"Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting","volume":"33","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC82","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev-cellbio-100814-125346","article-title":"Translating the genome in time and space: specialized ribosomes, RNA regulons, and RNA-binding proteins","volume":"31","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2024022816402191300_BST-2023-1116CC83","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/s1535-6108(03)00134-x","article-title":"Regulation of HDM2 activity by the ribosomal protein L11","volume":"3","year":"2000","journal-title":"Cancer Cell"},{"key":"2024022816402191300_BST-2023-1116CC84","doi-asserted-by":"publisher","first-page":"e68667","DOI":"10.1371\/journal.pone.0068667","article-title":"Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"2024022816402191300_BST-2023-1116CC85","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1038\/onc.2012.289","article-title":"Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop","volume":"32","year":"2013","journal-title":"Oncogene"},{"key":"2024022816402191300_BST-2023-1116CC86","doi-asserted-by":"publisher","first-page":"22730","DOI":"10.1074\/jbc.M111.223651","article-title":"Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress","volume":"286","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2024022816402191300_BST-2023-1116CC87","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1080\/15476286.2016.1243646","article-title":"Assembly and trafficking of box C\/D and H\/ACA snoRNPs","volume":"14","year":"2017","journal-title":"RNA Biol."},{"key":"2024022816402191300_BST-2023-1116CC88","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1101\/gad.908401","article-title":"Coilin forms the bridge between Cajal bodies and SMN, the Spinal Muscular Atrophy protein","volume":"15","year":"2001","journal-title":"Genes Dev."},{"key":"2024022816402191300_BST-2023-1116CC89","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1083\/jcb.200311121","article-title":"In vivo kinetics of Cajal body components","volume":"164","year":"2004","journal-title":"J. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC90","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.1016\/j.cell.2021.05.008","article-title":"DMA-tudor interaction modules control the specificity of in vivo condensates","volume":"184","year":"2021","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC91","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1093\/nar\/gkl374","article-title":"Depletion of SMN by RNA interference in HeLa cells induces defects in Cajal body formation","volume":"34","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2024022816402191300_BST-2023-1116CC92","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1091\/mbc.E06","article-title":"Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies","volume":"17","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"2024022816402191300_BST-2023-1116CC93","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nsmb.1783","article-title":"Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis","volume":"17","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2024022816402191300_BST-2023-1116CC94","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s00418-012-0921-8","article-title":"Reorganization of Cajal bodies and nucleolar targeting of coilin in motor neurons of type I spinal muscular atrophy","volume":"137","year":"2012","journal-title":"Histochem. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC95","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1093\/hmg\/ddp009","article-title":"The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy","volume":"18","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC96","doi-asserted-by":"publisher","first-page":"10989","DOI":"10.1128\/MCB.25.24.10989-11004.2005","article-title":"Specific sequence features, recognized by the SMN complex, identify snRNAs and determine their fate as snRNPs","volume":"25","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC97","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1093\/hmg\/11.15.1785","article-title":"SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta","volume":"15","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC98","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1083\/jcb.200108114","article-title":"The importin-\u03b2 binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro","volume":"156","year":"2002","journal-title":"J. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC99","doi-asserted-by":"publisher","first-page":"3418","DOI":"10.1038\/s41467-023-39150-9","article-title":"Co-translational binding of importins to nascent proteins","volume":"14","year":"2023","journal-title":"Nat. Commun."},{"key":"2024022816402191300_BST-2023-1116CC100","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation","volume":"36","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"2024022816402191300_BST-2023-1116CC101","doi-asserted-by":"publisher","first-page":"27734","DOI":"10.1074\/jbc.M109.008177","article-title":"Specification of neuronal polarity regulated by local translation of CRMP2 and tau via the mTOR-p70S6K pathway","volume":"284","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2024022816402191300_BST-2023-1116CC102","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","year":"2008","journal-title":"Science"},{"key":"2024022816402191300_BST-2023-1116CC103","doi-asserted-by":"publisher","first-page":"42818","DOI":"10.1074\/jbc.M103237200","article-title":"Brain-derived neurotrophic factor enhances neuronal translation by activating multiple initiation processes: comparison with the effects of insulin","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2024022816402191300_BST-2023-1116CC104","doi-asserted-by":"publisher","first-page":"6318","DOI":"10.1093\/hmg\/ddu350","article-title":"SMN regulates axonal local translation via miR-183\/mTOR pathway","volume":"23","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC105","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1083\/jcb.200304128","article-title":"Smn, the spinal muscular atrophy\u2013determining gene product, modulates axon growth and localization of \u03b2-actin mRNA in growth cones of motoneurons","volume":"163","year":"2003","journal-title":"J. Cell Biol."},{"key":"2024022816402191300_BST-2023-1116CC106","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1093\/hmg\/ddq226","article-title":"PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons","volume":"19","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC107","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/J.PHRS.2016.05.023","article-title":"Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt\/mTOR in experimental models of spinal muscular atrophy","volume":"111","year":"2016","journal-title":"Pharmacol. Res."},{"key":"2024022816402191300_BST-2023-1116CC108","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1741-7015-7-14","article-title":"Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy","volume":"7","year":"2009","journal-title":"BMC Med."},{"key":"2024022816402191300_BST-2023-1116CC109","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.yexcr.2003.12.032","article-title":"Role of the p70S6K pathway in regulating the actin cytoskeleton and cell migration","volume":"296","year":"2004","journal-title":"Exp. Cell Res."},{"key":"2024022816402191300_BST-2023-1116CC110","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.tins.2009.11.003","article-title":"mTOR signaling: at the crossroads of plasticity, memory and disease","volume":"33","year":"2010","journal-title":"Trends Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC111","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3390\/cells10113015","article-title":"Fine-tuning of mTOR mRNA and nucleolin complexes by SMN","volume":"10","year":"2021","journal-title":"Cells"},{"key":"2024022816402191300_BST-2023-1116CC112","doi-asserted-by":"publisher","first-page":"533","DOI":"10.2174\/1566524016666160523143937","article-title":"(2016) The role of the PERK\/eIF2\u03b1\/ATF4\/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress 2016","volume":"16"},{"key":"2024022816402191300_BST-2023-1116CC113","doi-asserted-by":"publisher","first-page":"dmm041350","DOI":"10.1242\/dmm.041350","article-title":"Modulating the ER stress response attenuates neurodegeneration in a C. elegans model of spinal muscular atrophy","volume":"13","year":"2020","journal-title":"Dis. Model Mech."},{"key":"2024022816402191300_BST-2023-1116CC114","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1261\/rna.056788.116","article-title":"A new cis-acting motif is required for the axonal SMN-dependent Anxa2 mRNA localization","volume":"23","year":"2017","journal-title":"RNA"},{"key":"2024022816402191300_BST-2023-1116CC115","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1523\/JNEUROSCI.2396-15.2016","article-title":"Deficiency of the survival of motor neuron protein impairs mRNA localization and local translation in the growth cone of motor neurons","volume":"36","year":"2016","journal-title":"J. Neurosci."},{"key":"2024022816402191300_BST-2023-1116CC116","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/dneu.22111","article-title":"Dynamics of survival of motor neuron (SMN) protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons","volume":"74","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"2024022816402191300_BST-2023-1116CC117","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1261\/rna.047373.114","article-title":"Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation","volume":"20","year":"2014","journal-title":"RNA"},{"key":"2024022816402191300_BST-2023-1116CC118","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1093\/hmg\/ddr046","article-title":"The COPI vesicle complex binds and moves with survival motor neuron within axons","volume":"20","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2024022816402191300_BST-2023-1116CC119","doi-asserted-by":"publisher","first-page":"5598","DOI":"10.1074\/jbc.M707304200","article-title":"In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein","volume":"283","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2024022816402191300_BST-2023-1116CC120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/B978-0-12-803685-3.00008-2","volume-title":"Spinal Muscular Atrophy","year":"2017"},{"key":"2024022816402191300_BST-2023-1116CC121","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnana.2016.00006","article-title":"Neuromuscular junctions as key contributors and therapeutic targets in spinal muscular atrophy","volume":"10","year":"2016","journal-title":"Front. Neuroanat."},{"key":"2024022816402191300_BST-2023-1116CC122","doi-asserted-by":"publisher","first-page":"111393","DOI":"10.1016\/j.celrep.2022.111393","article-title":"SMN controls neuromuscular junction integrity through U7 snRNP","volume":"40","year":"2022","journal-title":"Cell Rep."},{"key":"2024022816402191300_BST-2023-1116CC123","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.conb.2016.04.004","article-title":"A role for the survival of motor neuron protein in mRNP assembly and transport","volume":"39","year":"2016","journal-title":"Curr. Opin. Neurobiol."},{"key":"2024022816402191300_BST-2023-1116CC124","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.cell.2011.06.013","article-title":"FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism","volume":"146","year":"2011","journal-title":"Cell"},{"key":"2024022816402191300_BST-2023-1116CC125","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.molcel.2018.06.032","article-title":"Hud is a neural translation enhancer acting on mTORC1-responsive genes and counteracted by the Y3 small non-coding RNA","volume":"71","year":"2018","journal-title":"Mol. Cell"},{"key":"2024022816402191300_BST-2023-1116CC126","doi-asserted-by":"publisher","first-page":"100346","DOI":"10.1016\/j.xcrm.2021.100346","article-title":"Spinal muscular atrophy: from approved therapies to future therapeutic targets for personalized medicine","volume":"2","year":"2021","journal-title":"Cell Rep. Med."},{"key":"2024022816402191300_BST-2023-1116CC127","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1056\/NEJMoa1706198","article-title":"Single-dose gene-replacement therapy for spinal muscular atrophy","volume":"377","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"2024022816402191300_BST-2023-1116CC128","doi-asserted-by":"publisher","first-page":"e2492","DOI":"10.1212\/WNL.0000000000007527","article-title":"Nusinersen in later-onset spinal muscular atrophy","volume":"92","year":"2019","journal-title":"Neurology"},{"key":"2024022816402191300_BST-2023-1116CC129","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/mus.27853","article-title":"Continued benefit of nusinersen initiated in the presymptomatic stage of spinal muscular atrophy: 5-year update of the NURTURE study","volume":"68","year":"2023","journal-title":"Muscle Nerve"},{"key":"2024022816402191300_BST-2023-1116CC130","doi-asserted-by":"publisher","first-page":"eadg6518","DOI":"10.1126\/science.adg6518","article-title":"Base editing rescue of spinal muscular atrophy in cells and in mice","volume":"380","year":"2023","journal-title":"Science"},{"key":"2024022816402191300_BST-2023-1116CC131","doi-asserted-by":"publisher","first-page":"e17683","DOI":"10.15252\/emmm.202317683","article-title":"PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice","volume":"15","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"2024022816402191300_BST-2023-1116CC132","doi-asserted-by":"publisher","first-page":"e1672","DOI":"10.1038\/cddis.2015.49","article-title":"Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity","volume":"6","year":"2015","journal-title":"Cell Death Dis."},{"key":"2024022816402191300_BST-2023-1116CC133","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.4103\/1673-5374.330593","article-title":"Protein synthesis modulation as a therapeutic approach for amyotrophic lateral sclerosis and frontotemporal dementia","volume":"17","year":"2022","journal-title":"Neural Regen. Res."},{"key":"2024022816402191300_BST-2023-1116CC134","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41419-020-2601-2","article-title":"Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis","volume":"11","year":"2020","journal-title":"Cell Death Dis."},{"key":"2024022816402191300_BST-2023-1116CC135","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.stem.2015.08.003","article-title":"Genome-wide RNA-seq of human motor neurons implicates selective ER stress activation in spinal muscular atrophy","volume":"17","year":"2015","journal-title":"Cell Stem Cell"},{"key":"2024022816402191300_BST-2023-1116CC136","doi-asserted-by":"publisher","first-page":"592234","DOI":"10.3389\/fphar.2020.592234","article-title":"Drug screening and drug repositioning as promising therapeutic approaches for spinal muscular atrophy treatment","volume":"11","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2024022816402191300_BST-2023-1116CC137","doi-asserted-by":"publisher","first-page":"e149446","DOI":"10.1172\/jci.insight.149446","article-title":"Combining multiomics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy","volume":"6","year":"2021","journal-title":"JCI Insight"},{"key":"2024022816402191300_BST-2023-1116CC138","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1093\/hmg\/ddad192","article-title":"A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models","volume":"33","year":"2023","journal-title":"Hum. Mol. Genet."}],"container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/52\/1\/465\/954637\/bst-2023-1116c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/52\/1\/465\/954637\/bst-2023-1116c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T16:40:55Z","timestamp":1709138455000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/52\/1\/465\/234096\/The-SMN-ribosome-interplay-a-new-opportunity-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":138,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,23]]},"published-print":{"date-parts":[[2024,2,28]]}},"URL":"https:\/\/doi.org\/10.1042\/bst20231116","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]}}}