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This review explores emerging evidence for roles of PMP22 in cholesterol homeostasis. First, we highlight dysregulation of lipid metabolism in PMP22-based forms of CMTD and recently-discovered interactions between PMP22 and cholesterol biosynthesis machinery. We then examine data that demonstrates PMP22 and cholesterol co-traffic in cells and co-localize in lipid rafts, including how disease-causing PMP22 mutations result in aberrations in cholesterol localization. Finally, we examine roles for interactions between PMP22 and ABCA1 in cholesterol efflux. Together, this emerging body of evidence suggests that PMP22 plays a role in facilitating enhanced cholesterol synthesis and trafficking necessary for production and maintenance of healthy myelin.<\/jats:p>","DOI":"10.1042\/bst20231359","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T09:14:41Z","timestamp":1720516481000},"page":"1747-1756","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Roles for PMP22 in Schwann cell cholesterol homeostasis in health and disease"],"prefix":"10.1042","volume":"52","author":[{"given":"Katherine M.","family":"Stefanski","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Medicine, Vanderbilt University School of Medicine, Nashville, TN 37240-7917, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason C.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medicine, Vanderbilt University School of Medicine, Nashville, TN 37240-7917, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2046-2862","authenticated-orcid":false,"given":"Charles R.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medicine, Vanderbilt University School of Medicine, Nashville, TN 37240-7917, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"2024082813112080900_BST-2023-1359CC1","doi-asserted-by":"publisher","first-page":"1041961","DOI":"10.3389\/FCHEM.2022.1041961\/BIBTEX","article-title":"Overview of myelin, major myelin lipids, and myelin-associated proteins","volume":"10","year":"2022","journal-title":"Front. 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