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In the past 10 years, researchers have discovered and investigated how loss of specific interactions and subcellular targeting for the protein kinase A catalytic subunit (PKAc) lead to cortisol-producing adenomas and the debilitating stress disorder adrenal Cushing's syndrome. This article reviews classical studies regarding PKA localization in glucocorticoid-producing adrenal cells and synthesizes recent evidence of disrupted PKA localization and selective regulatory interactions in adrenal pathology.<\/jats:p>","DOI":"10.1042\/bst20240444","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T10:33:26Z","timestamp":1728038006000},"page":"2231-2241","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disruptions to protein kinase A localization in adrenal pathology"],"prefix":"10.1042","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1713-4473","authenticated-orcid":false,"given":"Mitchell H.","family":"Omar","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"2024103013120242800_BST-2024-0444CC1","first-page":"239","volume-title":"Current Topics in Developmental Biology","author":"Thomas","year":"2013"},{"key":"2024103013120242800_BST-2024-0444CC2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1001\/jama.2023.11305","article-title":"Cushing syndrome: a review","volume":"330","year":"2023","journal-title":"JAMA"},{"key":"2024103013120242800_BST-2024-0444CC3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.tem.2013.05.003","article-title":"Primary aldosteronism: emerging trends","volume":"24","year":"2013","journal-title":"Trends Endocrinol. 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