{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:02:27Z","timestamp":1790240547613,"version":"4.1.0"},"reference-count":147,"publisher":"Portland Press Ltd.","issue":"10","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Education, Australian Government","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"University of Canberra","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Chism Indigenous PhD Top-up Scholarship","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Ormond College Indigenous Scholarship","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Ormond College Peter Callow Memorial Scholarship","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"UoM | Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Walter and Eliza Hall Institute","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rhinovirus (RV) infection is responsible for the majority of cases of viral exacerbations of asthma. Understanding the cellular and molecular mechanisms that cause asthma exacerbations is an absolute requirement for the development of effective treatments. Emerging literature suggests that cell death may have an important role in RV-induced exacerbations. Several types of programmed cell death (PCD) have been implicated in asthma, including apoptosis, necroptosis, pyroptosis, and ferroptosis. Increased presence of apoptotic airway epithelial cells in the sputum of adult and paediatric asthma patients is suggestive of defects in apoptosis. Elevated levels of phosphorylated mixed lineage kinase domain-like protein and receptor-interacting serine\/threonine-protein kinase 3, markers of active necroptosis, have been found in the serum of asthmatic patients. Gasdermin B, a member of the gasdermin family of pyroptosis executioner proteins, has a strong genetic linkage to severe asthma. Expression level of GSDMB correlated with asthma exacerbations and antiviral pathways. Lipid peroxidation and increased airway iron levels, both suggestive of ferroptosis, have been observed in asthma patients. RV infection of epithelial cells triggers an inflammatory response, which can provide the necessary pro-inflammatory chemokines and cytokines to initiate PCD, such as tumour necrosis factor-\u03b1. RV exploits PCD such as apoptosis, necroptosis, pyroptosis, and ferroptosis to aid its replication and release, while modulating them probably to limit immune response. In the present review, we investigate the concept that pro-inflammatory PCD pathways modulated by RV infection in the context of asthma lead to prolonged inflammatory and immune responses that are key to asthma exacerbations.<\/jats:p>","DOI":"10.1042\/bst20250090","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:20:27Z","timestamp":1790238027000},"page":"1359-1373","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unmasking programmed cell death in rhinovirus-driven asthma pathology"],"prefix":"10.1042","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8467-8091","authenticated-orcid":false,"given":"Wayne","family":"Cawthorne","sequence":"first","affiliation":[{"name":"1Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia"},{"name":"2Department of Medical Biology, University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-4044","authenticated-orcid":false,"given":"Youming","family":"Zhang","sequence":"additional","affiliation":[{"name":"3National Heart and Lung Institute, Imperial College, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Val","sequence":"additional","affiliation":[{"name":"4Faculty of Science and Technology, University of Canberra, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Nelson","sequence":"additional","affiliation":[{"name":"4Faculty of Science and Technology, University of Canberra, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Raevski","sequence":"additional","affiliation":[{"name":"4Faculty of Science and Technology, University of Canberra, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9320-2717","authenticated-orcid":false,"given":"Kazuhiro","family":"Ito","sequence":"additional","affiliation":[{"name":"3National Heart and Lung Institute, Imperial College, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-4976","authenticated-orcid":false,"given":"Reena","family":"Ghildyal","sequence":"additional","affiliation":[{"name":"4Faculty of Science and Technology, University of Canberra, Canberra, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"2026092404200510300_B1","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1002\/alr.21609","article-title":"Asthma: definitions and pathophysiology","volume":"5","author":"Mims","year":"2015","journal-title":"Int. Forum Allergy Rhinol."},{"key":"2026092404200510300_B2","volume-title":"Chronic Respiratory Conditions: Asthma","author":"Australian Institute of Health and Welfare","year":"2024"},{"key":"2026092404200510300_B3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.jaip.2022.01.006","article-title":"Rhinovirus infections and their roles in asthma: etiology and exacerbations","volume":"10","author":"Jackson","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"2026092404200510300_B4","doi-asserted-by":"publisher","first-page":"7418","DOI":"10.1128\/JVI.02290-09","article-title":"The ABCs of rhinoviruses, wheezing, and asthma","volume":"84","author":"Gern","year":"2010","journal-title":"J. Virol."},{"key":"2026092404200510300_B5","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/S0140-6736(02)07953-9","article-title":"Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study","volume":"359","author":"Corne","year":"2002","journal-title":"Lancet"},{"key":"2026092404200510300_B6","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1111\/j.1365-2222.2005.02244.x","article-title":"Persistence of rhinovirus RNA after asthma exacerbation in children","volume":"35","author":"Kling","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"2026092404200510300_B7","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/s41419-018-0306-6","article-title":"Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death","volume":"9","author":"Lotzerich","year":"2018","journal-title":"Cell Death Dis."},{"key":"2026092404200510300_B8","doi-asserted-by":"publisher","first-page":"9651","DOI":"10.1128\/JVI.00316-11","article-title":"Human rhinovirus 2 induces the autophagic pathway and replicates more efficiently in autophagic cells","volume":"85","author":"Klein","year":"2011","journal-title":"J. Virol."},{"key":"2026092404200510300_B9","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1038\/s41598-018-19839-4","article-title":"Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation","volume":"8","author":"Croft","year":"2018","journal-title":"Sci. Rep."},{"key":"2026092404200510300_B10","doi-asserted-by":"publisher","first-page":"406","DOI":"10.3389\/fcimb.2019.00406","article-title":"ZBP1 and TAK1: master regulators of NLRP3 Inflammasome\/Pyroptosis, Apoptosis, and necroptosis (PAN-optosis)","volume":"9","author":"Malireddi","year":"2019","journal-title":"Front. Cell Infect. Microbiol."},{"key":"2026092404200510300_B11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br. J. Cancer"},{"key":"2026092404200510300_B12","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"2026092404200510300_B13","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"2026092404200510300_B14","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","article-title":"Mechanisms of BCL-2 family proteins in mitochondrial apoptosis","volume":"24","author":"Czabotar","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026092404200510300_B15","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3390\/v13040629","article-title":"Rhinovirus and cell death","volume":"13","author":"Kerr","year":"2021","journal-title":"Viruses"},{"key":"2026092404200510300_B16","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3892\/ijmm.2019.4244","article-title":"RIP1\/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)","volume":"44","author":"Liu","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"2026092404200510300_B17","doi-asserted-by":"publisher","first-page":"3309.e5","DOI":"10.1016\/j.celrep.2019.08.055","article-title":"Viral MLKL homologs subvert necroptotic cell death by sequestering cellular RIPK3","volume":"28","author":"Petrie","year":"2019","journal-title":"Cell Rep."},{"key":"2026092404200510300_B18","doi-asserted-by":"publisher","first-page":"16258","DOI":"10.1038\/nmicrobiol.2016.258","article-title":"EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation","volume":"2","author":"Pearson","year":"2017","journal-title":"Nat. Microbiol."},{"key":"2026092404200510300_B19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41419-022-04740-w","article-title":"The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL","volume":"13","author":"Jacobsen","year":"2022","journal-title":"Cell Death Dis."},{"key":"2026092404200510300_B20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.tcb.2022.05.008","article-title":"The web of death: the expanding complexity of necroptotic signaling","volume":"33","author":"Horne","year":"2023","journal-title":"Trends Cell Biol."},{"key":"2026092404200510300_B21","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"2026092404200510300_B22","doi-asserted-by":"publisher","first-page":"5322","DOI":"10.1073\/pnas.1200012109","article-title":"Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis","volume":"109","author":"Zhao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026092404200510300_B23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/cdd.2016.78","article-title":"Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death","volume":"24","author":"De Almagro","year":"2017","journal-title":"Cell Death Differ."},{"key":"2026092404200510300_B24","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1080\/15384047.2016.1210732","article-title":"Necroptosis: a new way of dying?","volume":"17","author":"Hanson","year":"2016","journal-title":"Cancer Biol. Ther."},{"key":"2026092404200510300_B25","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s13105-022-00909-1","article-title":"Pyroptosis in inflammation-related respiratory disease","volume":"78","author":"Feng","year":"2022","journal-title":"J. Physiol. Biochem."},{"key":"2026092404200510300_B26","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.2147\/JIR.S352563","article-title":"Role of pyroptosis in respiratory diseases and its therapeutic potential","volume":"15","author":"Liu","year":"2022","journal-title":"J. Inflamm Res."},{"key":"2026092404200510300_B27","doi-asserted-by":"publisher","first-page":"7858","DOI":"10.1073\/pnas.1607769113","article-title":"GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes","volume":"113","author":"Aglietti","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026092404200510300_B28","doi-asserted-by":"publisher","first-page":"1178662","DOI":"10.3389\/fimmu.2023.1178662","article-title":"Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors","volume":"14","author":"Dai","year":"2023","journal-title":"Front. Immunol."},{"key":"2026092404200510300_B29","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.1038\/s41467-022-30232-8","article-title":"Gasdermin-A3 pore formation propagates along variable pathways","volume":"13","author":"Mari","year":"2022","journal-title":"Nat. Commun."},{"key":"2026092404200510300_B30","doi-asserted-by":"publisher","first-page":"e98321","DOI":"10.15252\/embj.201798321","article-title":"Mechanism of membrane pore formation by human gasdermin-D","volume":"37","author":"Mulvihill","year":"2018","journal-title":"EMBO J."},{"key":"2026092404200510300_B31","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1111\/j.1462-5822.2006.00751.x","article-title":"Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages","volume":"8","author":"Fink","year":"2006","journal-title":"Cell. Microbiol."},{"key":"2026092404200510300_B32","doi-asserted-by":"publisher","first-page":"4561","DOI":"10.1038\/s41467-020-18443-3","article-title":"Indirect regulation of HMGB1 release by gasdermin D","volume":"11","author":"Volchuk","year":"2020","journal-title":"Nat. Commun."},{"key":"2026092404200510300_B33","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"2026092404200510300_B34","doi-asserted-by":"publisher","first-page":"106013","DOI":"10.1016\/j.biocel.2021.106013","article-title":"Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics","volume":"136","author":"Mishra","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2026092404200510300_B35","doi-asserted-by":"publisher","first-page":"11282","DOI":"10.1073\/pnas.1117765109","article-title":"Critical role for calcium mobilization in activation of the NLRP3 inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026092404200510300_B36","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2026092404200510300_B37","doi-asserted-by":"publisher","first-page":"e2213777120","DOI":"10.1073\/pnas.2213777120","article-title":"Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT)","volume":"120","author":"Zhou","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026092404200510300_B38","doi-asserted-by":"publisher","first-page":"eabd0811","DOI":"10.1126\/science.abd0811","article-title":"Human NLRP1 is a sensor for double-stranded RNA","volume":"371","author":"Bauernfried","year":"2021","journal-title":"Science"},{"key":"2026092404200510300_B39","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1128\/IAI.01003-12","article-title":"Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP","volume":"81","author":"Liao","year":"2013","journal-title":"Infect. Immun."},{"key":"2026092404200510300_B40","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"2026092404200510300_B41","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/s41418-023-01143-y","article-title":"Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells","volume":"30","author":"Oltra","year":"2023","journal-title":"Cell Death Differ."},{"key":"2026092404200510300_B42","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1038\/s41418-023-01163-8","article-title":"Regulating GSDMB pore formation: to ignite or inhibit?","volume":"30","author":"Ruan","year":"2023","journal-title":"Cell Death Differ."},{"key":"2026092404200510300_B43","doi-asserted-by":"publisher","first-page":"E1128","DOI":"10.1073\/pnas.1616783114","article-title":"Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein","volume":"114","author":"Chao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026092404200510300_B44","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"2026092404200510300_B45","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1126\/science.122.3168.501","article-title":"Nutrition needs of mammalian cells in tissue culture","volume":"122","author":"Eagle","year":"1955","journal-title":"Science"},{"key":"2026092404200510300_B46","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/0896-6273(89)90043-3","article-title":"Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress","volume":"2","author":"Murphy","year":"1989","journal-title":"Neuron"},{"key":"2026092404200510300_B47","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/s41419-020-03118-0","article-title":"Excessive phospholipid peroxidation distinguishes ferroptosis from other cell death modes including pyroptosis","volume":"11","author":"Wiernicki","year":"2020","journal-title":"Cell Death Dis."},{"key":"2026092404200510300_B48","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.tips.2021.05.001","article-title":"Iron metabolism: pathophysiology and pharmacology","volume":"42","author":"Roemhild","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"2026092404200510300_B49","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","article-title":"Role of GPX4 in ferroptosis and its pharmacological implication","volume":"133","author":"Seibt","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"2026092404200510300_B50","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0005-2760(82)90150-3","article-title":"Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides","volume":"710","author":"Ursini","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"2026092404200510300_B51","doi-asserted-by":"publisher","first-page":"102703","DOI":"10.1016\/j.redox.2023.102703","article-title":"The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1","volume":"62","author":"Cheff","year":"2023","journal-title":"Redox Biol."},{"key":"2026092404200510300_B52","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1099\/vir.0.80754-0","article-title":"Apoptotic events induced by human rhinovirus infection","volume":"86","author":"Deszcz","year":"2005","journal-title":"J. Gen. Virol."},{"key":"2026092404200510300_B53","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41579-018-0005-4","article-title":"The life cycle of non-polio enteroviruses and how to target it","volume":"16","author":"Baggen","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"2026092404200510300_B54","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1128\/CMR.00077-12","article-title":"Human rhinoviruses","volume":"26","author":"Jacobs","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"2026092404200510300_B55","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.jaci.2010.04.010","article-title":"Analysis of the complete genome sequences of human rhinovirus","volume":"125","author":"Palmenberg","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026092404200510300_B56","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1128\/JVI.77.1.45-56.2003","article-title":"The major apoptotic pathway activated and suppressed by poliovirus","volume":"77","author":"Belov","year":"2003","journal-title":"J. Virol."},{"key":"2026092404200510300_B57","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0042-6822(03)00242-3","article-title":"Bcl-2 and Bcl-xL overexpression inhibits cytochrome c release, activation of multiple caspases, and virus release following coxsackievirus B3 infection","volume":"313","author":"Carthy","year":"2003","journal-title":"Virology"},{"key":"2026092404200510300_B58","doi-asserted-by":"publisher","first-page":"6066","DOI":"10.1128\/JVI.73.7.6066-6072.1999","article-title":"Poliovirus induces apoptosis in the mouse central nervous system","volume":"73","author":"Girard","year":"1999","journal-title":"J. Virol."},{"key":"2026092404200510300_B59","doi-asserted-by":"publisher","first-page":"6856","DOI":"10.1128\/jvi.70.10.6856-6861.1996","article-title":"Theiler's murine encephalomyelitis virus kills restrictive but not permissive cells by apoptosis","volume":"70","author":"Jelachich","year":"1996","journal-title":"J. Virol."},{"key":"2026092404200510300_B60","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1146\/annurev.med.48.1.267","article-title":"Apoptosis and disease: regulation and clinical relevance of programmed cell death","volume":"48","author":"Rudin","year":"1997","journal-title":"Annu. Rev. Med."},{"key":"2026092404200510300_B61","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1054-8807(03)00077-2","article-title":"Cardiomyocyte apoptosis in experimental coxsackievirus B3 myocarditis","volume":"12","author":"Saraste","year":"2003","journal-title":"Cardiovasc. Pathol."},{"key":"2026092404200510300_B62","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1365-2613.2001.iep195.x","article-title":"Viruses and apoptosis","volume":"82","author":"Thomson","year":"2001","journal-title":"Int. J. Exp. Pathol."},{"key":"2026092404200510300_B63","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.virol.2003.11.026","article-title":"NuMA and nuclear lamins are cleaved during viral infection\u2013inhibition of caspase activity prevents cleavage and rescues HeLa cells from measles virus-induced but not from rhinovirus 1B-induced cell death","volume":"320","author":"Taimen","year":"2004","journal-title":"Virology"},{"key":"2026092404200510300_B64","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.3389\/fimmu.2017.01220","article-title":"Induction of apoptosis and subsequent phagocytosis of virus-infected cells as an antiviral mechanism","volume":"8","author":"Nainu","year":"2017","journal-title":"Front. Immunol."},{"key":"2026092404200510300_B65","doi-asserted-by":"publisher","first-page":"115070","DOI":"10.1016\/j.celrep.2024.115070","article-title":"Early host defense against virus infections","volume":"43","author":"Paludan","year":"2024","journal-title":"Cell Rep."},{"key":"2026092404200510300_B66","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1084\/jem.20041901","article-title":"Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus","volume":"201","author":"Wark","year":"2005","journal-title":"J. Exp. Med."},{"key":"2026092404200510300_B67","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/sj.cdd.4401626","article-title":"Nucleocytoplasmic transport in apoptosis","volume":"12","author":"Ferrando-May","year":"2005","journal-title":"Cell Death Differ."},{"key":"2026092404200510300_B68","doi-asserted-by":"publisher","first-page":"7349","DOI":"10.1128\/JVI.01748-08","article-title":"Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport","volume":"83","author":"Ghildyal","year":"2009","journal-title":"J. Virol."},{"key":"2026092404200510300_B69","doi-asserted-by":"publisher","first-page":"8787","DOI":"10.1128\/JVI.76.17.8787-8796.2002","article-title":"Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirus","volume":"76","author":"Gustin","year":"2002","journal-title":"J. Virol."},{"key":"2026092404200510300_B70","doi-asserted-by":"publisher","first-page":"e71316","DOI":"10.1371\/journal.pone.0071316","article-title":"Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells","volume":"8","author":"Walker","year":"2013","journal-title":"PloS ONE"},{"key":"2026092404200510300_B71","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1183\/09031936.02.00226302","article-title":"Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma","volume":"19","author":"Wark","year":"2002","journal-title":"Eur. Respir. J."},{"key":"2026092404200510300_B72","doi-asserted-by":"publisher","first-page":"e02472","DOI":"10.1128\/JVI.02472-16","article-title":"Differential disruption of nucleocytoplasmic trafficking pathways by rhinovirus 2a proteases","volume":"91","author":"Watters","year":"2017","journal-title":"J. Virol."},{"key":"2026092404200510300_B73","doi-asserted-by":"publisher","first-page":"10874","DOI":"10.1128\/JVI.00718-11","article-title":"Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypes","volume":"85","author":"Watters","year":"2011","journal-title":"J. Virol."},{"key":"2026092404200510300_B74","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.3390\/v13122402","article-title":"RIPK1 is cleaved by 3C protease of rhinovirus a and b strains and minor and major groups","volume":"13","author":"Croft","year":"2021","journal-title":"Viruses"},{"key":"2026092404200510300_B75","doi-asserted-by":"publisher","first-page":"3782","DOI":"10.1128\/JVI.02076-07","article-title":"Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking","volume":"82","author":"de Jong","year":"2008","journal-title":"J. Virol."},{"key":"2026092404200510300_B76","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13567-014-0087-6","article-title":"Topology and biological function of enterovirus non-structural protein 2B as a member of the viroporin family","volume":"45","author":"Ao","year":"2014","journal-title":"Vet. Res."},{"key":"2026092404200510300_B77","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.jaci.2008.08.013","article-title":"Host immune responses to rhinovirus: mechanisms in asthma","volume":"122","author":"Kelly","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026092404200510300_B78","doi-asserted-by":"publisher","first-page":"621","DOI":"10.4049\/jimmunol.156.2.621","article-title":"Rhinovirus enters but does not replicate inside monocytes and airway macrophages","volume":"156","author":"Gern","year":"1996","journal-title":"J. Immunol."},{"key":"2026092404200510300_B79","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1164\/rccm.201406-1039OC","article-title":"IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo","volume":"190","author":"Jackson","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026092404200510300_B80","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/s12967-015-0645-3","article-title":"Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33","volume":"13","author":"Calven","year":"2015","journal-title":"J. Transl. Med."},{"key":"2026092404200510300_B81","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1600-065X.2011.01031.x","article-title":"Rhinoviruses, allergic inflammation, and asthma","volume":"242","author":"Gavala","year":"2011","journal-title":"Immunol. Rev."},{"key":"2026092404200510300_B82","doi-asserted-by":"publisher","first-page":"e63365","DOI":"10.1371\/journal.pone.0063365","article-title":"The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells","volume":"8","author":"Piper","year":"2013","journal-title":"PloS One"},{"key":"2026092404200510300_B83","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1158\/0008-5472.CAN-13-1283","article-title":"Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma","volume":"74","author":"Nomura","year":"2014","journal-title":"Cancer Res."},{"key":"2026092404200510300_B84","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1165\/rcmb.2013-0032OC","article-title":"Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells","volume":"49","author":"Triantafilou","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026092404200510300_B85","doi-asserted-by":"publisher","first-page":"eaay2002","DOI":"10.1126\/science.aay2002","article-title":"Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia","volume":"370","author":"Robinson","year":"2020","journal-title":"Science"},{"key":"2026092404200510300_B86","doi-asserted-by":"publisher","first-page":"e60609","DOI":"10.7554\/eLife.60609","article-title":"Diverse viral proteases activate the NLRP1 inflammasome","volume":"10","author":"Tsu","year":"2021","journal-title":"eLife"},{"key":"2026092404200510300_B87","doi-asserted-by":"publisher","first-page":"e01069","DOI":"10.1128\/JVI.01069-17","article-title":"Enterovirus 71 inhibits pyroptosis through cleavage of gasdermin D","volume":"91","author":"Lei","year":"2017","journal-title":"J. Virol."},{"key":"2026092404200510300_B88","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.celrep.2015.05.047","article-title":"Reciprocal regulation between enterovirus 71 and the NLRP3 inflammasome","volume":"12","author":"Wang","year":"2015","journal-title":"Cell Rep."},{"key":"2026092404200510300_B89","doi-asserted-by":"publisher","first-page":"e1006123","DOI":"10.1371\/journal.ppat.1006123","article-title":"EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex","volume":"13","author":"Wang","year":"2017","journal-title":"PLoS Pathog."},{"key":"2026092404200510300_B90","doi-asserted-by":"publisher","first-page":"101850","DOI":"10.1016\/j.jbc.2022.101850","article-title":"Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection","volume":"298","author":"Dong","year":"2022","journal-title":"J. Biol. Chem."},{"key":"2026092404200510300_B91","doi-asserted-by":"publisher","first-page":"E393","DOI":"10.1002\/lary.27510","article-title":"ROS is involved in disruption of tight junctions of human nasal epithelial cells induced by HRV16","volume":"128","author":"Kim","year":"2018","journal-title":"Laryngoscope"},{"key":"2026092404200510300_B92","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1056\/NEJMoa1211592","article-title":"Rhinovirus wheezing illness and genetic risk of childhood-onset asthma","volume":"368","author":"Caliskan","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"2026092404200510300_B93","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1183\/09031936.00154509","article-title":"17q21 variants modify the association between early respiratory infections and asthma","volume":"36","author":"Smit","year":"2010","journal-title":"Eur. Respir. J."},{"key":"2026092404200510300_B94","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1164\/rccm.202305-0934OC","article-title":"17q21 variants disturb mucosal host defense in childhood asthma","volume":"209","author":"Jakwerth","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026092404200510300_B95","doi-asserted-by":"publisher","first-page":"170","DOI":"10.5492\/wjccm.v10.i5.170","article-title":"Orosomucoid-like protein 3, rhinovirus and asthma","volume":"10","author":"Zhang","year":"2021","journal-title":"World J. Crit. Care Med."},{"key":"2026092404200510300_B96","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/S2213-2600(20)30011-4","article-title":"Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study","volume":"8","author":"Ober","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"2026092404200510300_B97","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1038\/s41401-021-00814-1","article-title":"Ferroptosis in viral infection: the unexplored possibility","volume":"43","author":"Wang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"2026092404200510300_B98","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1164\/rccm.201311-2069OE","article-title":"Theirs but to die and do: primary lysis of eosinophils and free eosinophil granules in asthma","volume":"189","author":"Persson","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026092404200510300_B99","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1136\/thx.17.1.69","article-title":"The shedding of the mucosa of the bronchial tree in asthma","volume":"17","author":"Naylor","year":"1962","journal-title":"Thorax"},{"key":"2026092404200510300_B100","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.tips.2006.07.006","article-title":"Resolution of airway disease: removal of inflammatory cells through apoptosis, egression or both?","volume":"27","author":"Uller","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"2026092404200510300_B101","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jaci.2013.03.024","article-title":"Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK\/ERK activation","volume":"132","author":"Kano","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026092404200510300_B102","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/cea.12255","article-title":"Primary lysis of eosinophils in severe desquamative asthma","volume":"44","author":"Persson","year":"2014","journal-title":"Clin. Exp. Allergy"},{"key":"2026092404200510300_B103","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1111\/all.15448","article-title":"Selective eosinophil necroptosis contributes to airway inflammation and remodeling in asthma","volume":"77","author":"He","year":"2022","journal-title":"Allergy"},{"key":"2026092404200510300_B104","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1067\/mai.2002.121460","article-title":"T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma","volume":"109","author":"Trautmann","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026092404200510300_B105","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3109\/02770903.2011.565848","article-title":"Epithelial apoptosis and loss in airways of children with asthma","volume":"48","author":"Zhou","year":"2011","journal-title":"J. Asthma"},{"key":"2026092404200510300_B106","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1164\/rccm.200607-1062OC","article-title":"Epithelial cell proliferation contributes to airway remodeling in severe asthma","volume":"176","author":"Cohen L","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2026092404200510300_B107","doi-asserted-by":"publisher","first-page":"948406","DOI":"10.1155\/2011\/948406","article-title":"Apoptosis and the airway epithelium","volume":"2011","author":"White","year":"2011","journal-title":"J. Allergy (Cairo)"},{"key":"2026092404200510300_B108","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3389\/fmed.2020.00191","article-title":"Airway remodeling in asthma","volume":"7","author":"Hough","year":"2020","journal-title":"Front. Med. (Lausanne)"},{"key":"2026092404200510300_B109","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1399-3038.2004.00155.x","article-title":"Creola bodies in wheezing infants predict the development of asthma","volume":"15","author":"Yamada","year":"2004","journal-title":"Pediatr. Allergy Immunol."},{"key":"2026092404200510300_B110","doi-asserted-by":"publisher","first-page":"375","DOI":"10.2332\/allergolint.09-OA-0165","article-title":"Creola bodies in infancy with respiratory syncytial virus bronchiolitis predict the development of asthma","volume":"59","author":"Yamada","year":"2010","journal-title":"Allergol Int."},{"key":"2026092404200510300_B111","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1067\/mai.2003.117","article-title":"Corticosteroid-induced apoptosis in mouse airway epithelium: effect in normal airways and after allergen-induced airway inflammation","volume":"111","author":"Dorscheid","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026092404200510300_B112","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/1465-9921-14-141","article-title":"Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis","volume":"14","author":"Hoffman","year":"2013","journal-title":"Respir. Res."},{"key":"2026092404200510300_B113","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1165\/rcmb.2001-0014OC","article-title":"Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation","volume":"27","author":"Truong-Tran","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026092404200510300_B114","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/bcpt.12163","article-title":"Eosinophil apoptosis as a therapeutic target in allergic asthma","volume":"114","author":"Ilmarinen","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"2026092404200510300_B115","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.resp.2014.12.004","article-title":"Neutrophils in asthma\u2014a review","volume":"209","author":"Ciepiela","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"2026092404200510300_B116","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1136\/thx.2009.120741","article-title":"Prosurvival activity for airway neutrophils in severe asthma","volume":"65","author":"Uddin","year":"2010","journal-title":"Thorax"},{"key":"2026092404200510300_B117","first-page":"4137","article-title":"The role of IL-25 in the reduction of oxidative stress and the apoptosis of airway epithelial cells with specific immunotherapy in an asthma mouse model","volume":"9","author":"Yuan","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"2026092404200510300_B118","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global strategy for asthma management and prevention: GINA executive summary","volume":"31","author":"Bateman","year":"2008","journal-title":"Eur. Respir. J."},{"key":"2026092404200510300_B119","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.pharmthera.2017.02.024","article-title":"Mitogen-activated protein kinases as therapeutic targets for asthma","volume":"174","author":"Khorasanizadeh","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"2026092404200510300_B120","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1136\/thoraxjnl-2018-212735","article-title":"MUC1 intracellular bioactivation mediates lung fibrosis","volume":"75","author":"Milara","year":"2020","journal-title":"Thorax"},{"key":"2026092404200510300_B121","doi-asserted-by":"publisher","first-page":"15080","DOI":"10.1002\/jcp.28148","article-title":"MUC1 downregulation promotes TNF-alpha-induced necroptosis in human bronchial epithelial cells via regulation of the RIPK1\/RIPK3 pathway","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"2026092404200510300_B122","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.lfs.2019.02.013","article-title":"Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells","volume":"221","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"key":"2026092404200510300_B123","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12931-024-02900-4","article-title":"Necroptosis plays a role in TL1A-induced airway inflammation and barrier damage in asthma","volume":"25","author":"Liu","year":"2024","journal-title":"Respir. Res."},{"key":"2026092404200510300_B124","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/imr.12543","article-title":"Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma","volume":"278","author":"Hansbro","year":"2017","journal-title":"Immunol. Rev."},{"key":"2026092404200510300_B125","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/jhg.2010.134","article-title":"Chromosome 17q21 SNP and severe asthma","volume":"56","author":"Binia","year":"2011","journal-title":"J. Hum. Genet."},{"key":"2026092404200510300_B126","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"2026092404200510300_B127","doi-asserted-by":"publisher","first-page":"2301232","DOI":"10.1183\/13993003.01232-2023","article-title":"Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation","volume":"63","author":"Liu","year":"2024","journal-title":"Eur. Respir. J."},{"key":"2026092404200510300_B128","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.jaci.2020.07.030","article-title":"Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways","volume":"147","author":"Li","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"2026092404200510300_B129","doi-asserted-by":"publisher","first-page":"109925","DOI":"10.1016\/j.biopha.2020.109925","article-title":"Bronchial epithelial pyroptosis promotes airway inflammation in a murine model of toluene diisocyanate-induced asthma","volume":"125","author":"Zhuang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"2026092404200510300_B130","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1093\/toxsci\/kfz099","article-title":"Blockade of the NLRP3\/Caspase-1 axis ameliorates airway neutrophilic inflammation in a toluene diisocyanate-induced murine asthma model","volume":"170","author":"Chen","year":"2019","journal-title":"Toxicol. Sci."},{"key":"2026092404200510300_B131","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s10753-021-01494-z","article-title":"Schisandrin B Attenuates Airway Inflammation and airway remodeling in asthma by inhibiting NLRP3 inflammasome activation and reducing pyroptosis","volume":"44","author":"Chen","year":"2021","journal-title":"Inflammation"},{"key":"2026092404200510300_B132","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.3390\/jcm8101615","article-title":"Targeting NLRP3 inflammasome activation in severe asthma","volume":"8","author":"Theofani","year":"2019","journal-title":"J. Clin. Med."},{"key":"2026092404200510300_B133","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1097\/WOX.0b013e318232389e","article-title":"Oxidative stress in asthma","volume":"4","author":"Sahiner","year":"2011","journal-title":"World Allergy Organ J."},{"key":"2026092404200510300_B134","doi-asserted-by":"publisher","first-page":"121358","DOI":"10.1016\/j.lfs.2022.121358","article-title":"Oxidative stress stimulation leads to cell-specific oxidant and antioxidant responses in airway resident and inflammatory cells","volume":"315","author":"Akel Bilgic","year":"2023","journal-title":"Life Sci."},{"key":"2026092404200510300_B135","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1111\/pai.12965","article-title":"Oxidative stress in asthma: part of the puzzle","volume":"29","author":"Sahiner","year":"2018","journal-title":"Pediatr. Allergy Immunol."},{"key":"2026092404200510300_B136","doi-asserted-by":"publisher","first-page":"1901340","DOI":"10.1183\/13993003.01340-2019","article-title":"Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma","volume":"55","author":"Ali","year":"2020","journal-title":"Eur. Respir. J."},{"key":"2026092404200510300_B137","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1513\/pats.200701-030AW","article-title":"Innate immunity in the pathogenesis of virus-induced asthma exacerbations","volume":"4","author":"Johnston","year":"2007","journal-title":"Proc. Am. Thorac Soc."},{"key":"2026092404200510300_B138","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1365-2222.2008.03157.x","article-title":"Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype","volume":"39","author":"Dougherty","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"2026092404200510300_B139","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1183\/09031936.00092410","article-title":"Association between human rhinovirus C and severity of acute asthma in children","volume":"37","author":"Bizzintino","year":"2011","journal-title":"Eur. Respir. J."},{"key":"2026092404200510300_B140","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1165\/rcmb.2008-0316OC","article-title":"Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses","volume":"41","author":"Thomas","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026092404200510300_B141","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1136\/thx.2009.125930","article-title":"Double-stranded RNA induces disproportionate expression of thymic stromal lymphopoietin versus interferon-beta in bronchial epithelial cells from donors with asthma","volume":"65","author":"Uller","year":"2010","journal-title":"Thorax"},{"key":"2026092404200510300_B142","doi-asserted-by":"publisher","first-page":"19:2025.10.19.683298","DOI":"10.1101\/2025.10.19.683298","article-title":"Transcriptomic profiling of bronchial epithelium reveals dysregulated interferon and inflammatory responses to rhinovirus in exacerbation-prone pediatric asthma","author":"Jayavelu","year":"2025","journal-title":"bioRxiv"},{"key":"2026092404200510300_B143","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/mi.2012.118","article-title":"Impaired innate interferon induction in severe therapy resistant atopic asthmatic children","volume":"6","author":"Edwards","year":"2013","journal-title":"Mucosal Immunol."},{"key":"2026092404200510300_B144","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1111\/cea.12767","article-title":"Impaired airway epithelial cell responses from children with asthma to rhinoviral infection","volume":"46","author":"Kicic","year":"2016","journal-title":"Clin. Exp. Allergy"},{"key":"2026092404200510300_B145","doi-asserted-by":"publisher","first-page":"4248","DOI":"10.1038\/s41598-018-22557-6","article-title":"Interferon-beta deficiency at asthma exacerbation promotes MLKL mediated necroptosis","volume":"8","author":"Cerps","year":"2018","journal-title":"Sci. Rep."},{"key":"2026092404200510300_B146","doi-asserted-by":"publisher","first-page":"00047","DOI":"10.1183\/23120541.00047-2017","article-title":"Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model","volume":"3","author":"Menzel","year":"2017","journal-title":"ERJ Open Res."},{"key":"2026092404200510300_B147","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1164\/rccm.201803-0438OC","article-title":"The ORMDL3 asthma gene regulates ICAM1 and has multiple effects on cellular inflammation","volume":"199","author":"Zhang","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/54\/10\/1359\/992352\/bst-2025-0090c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/54\/10\/1359\/992352\/bst-2025-0090c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:20:29Z","timestamp":1790238029000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/54\/10\/1359\/238106\/Unmasking-programmed-cell-death-in-rhinovirus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":147,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,24]]},"published-print":{"date-parts":[[2026,10,28]]}},"URL":"https:\/\/doi.org\/10.1042\/bst20250090","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,9,24]]}}}