{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:28:06Z","timestamp":1792232886647,"version":"4.4.0"},"reference-count":89,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MOST | National Natural Science Foundation of China","award":["31972537"],"award-info":[{"award-number":["31972537"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a highly conserved, multifunctional DNA\/RNA-binding protein that regulates gene expression at both transcriptional and post-transcriptional levels. In skeletal muscle, hnRNPK is essential for development, regeneration, and homeostasis, influencing satellite cell activation, myoblast proliferation and differentiation, and myofiber maturation. Its dysregulation is linked to muscle atrophy, degenerative diseases, and impaired regeneration. This review summarizes current knowledge of hnRNPK\u2019s molecular structure, subcellular localization and dynamics, and interactions with nucleic acids and proteins. We highlight its roles in myogenic differentiation, gene expression control, signaling pathway cross-talk, and skeletal muscle development. We also discuss the potential of hnRNPK as a diagnostic biomarker and therapeutic target in muscle disorders, and outline key directions for future research to resolve outstanding questions about its complex regulatory functions. Together, these insights provide a framework for advancing muscle biology and improving the management of muscle-related diseases.<\/jats:p>","DOI":"10.1042\/bst20250557","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:46:30Z","timestamp":1779353190000},"page":"571-584","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["RNA-binding protein hnRNPK: a multifunctional regulator of skeletal muscle biology and disease"],"prefix":"10.1042","volume":"54","author":[{"given":"Kejin","family":"Ren","sequence":"first","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Zhou","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijia","family":"An","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Cheng","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"},{"name":"2Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Meng","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"},{"name":"2Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cencen","family":"Li","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"},{"name":"2Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Xu","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"},{"name":"2Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"},{"name":"2Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-9312","authenticated-orcid":false,"given":"Yongjie","family":"Xu","sequence":"additional","affiliation":[{"name":"1College of Life Science, Xinyang Normal University, Xinyang 464000, China"},{"name":"2Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountain, Xinyang Normal University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"2026052104462611400_B1","doi-asserted-by":"publisher","first-page":"e649","DOI":"10.1002\/mco2.649","article-title":"Skeletal muscle: molecular structure, myogenesis, biological functions, and diseases","volume":"5","author":"Feng","year":"2024","journal-title":"MedComm. (2020)"},{"key":"2026052104462611400_B2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s00018-023-05096-w","article-title":"MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury","volume":"81","author":"Jiang","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"2026052104462611400_B3","doi-asserted-by":"publisher","first-page":"102136","DOI":"10.1016\/j.gde.2023.102136","article-title":"Exploring new roles for RNA-binding proteins in epigenetic and gene regulation","volume":"84","author":"Avila-Lopez","year":"2024","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2026052104462611400_B4","doi-asserted-by":"publisher","first-page":"102234","DOI":"10.1016\/j.arr.2024.102234","article-title":"The role and mechanism of RNA-binding proteins in bone metabolism and osteoporosis","volume":"96","author":"Wu","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"2026052104462611400_B5","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.7150\/thno.113312","article-title":"Old players and new insights: unraveling the role of RNA-binding proteins in brain tumors","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"key":"2026052104462611400_B6","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.celrep.2016.06.095","article-title":"Targeted mRNA decay by RNA binding protein AUF1 regulates adult muscle stem cell fate, promoting skeletal muscle integrity","volume":"16","author":"Chenette","year":"2016","journal-title":"Cell Rep."},{"key":"2026052104462611400_B7","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.yexcr.2019.05.004","article-title":"Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production","volume":"381","author":"Yin","year":"2019","journal-title":"Exp. Cell. Res."},{"key":"2026052104462611400_B8","doi-asserted-by":"publisher","first-page":"9540","DOI":"10.1074\/jbc.M116.773671","article-title":"Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts","volume":"292","author":"Espinoza-Lewis","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2026052104462611400_B9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/s42003-022-03253-8","article-title":"Cell environment shapes TDP-43 function with implications in neuronal and muscle disease","volume":"5","author":"Susnjar","year":"2022","journal-title":"Commun. Biol."},{"key":"2026052104462611400_B10","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.molcel.2014.06.035","article-title":"Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis","volume":"55","author":"Singh","year":"2014","journal-title":"Mol. Cell"},{"key":"2026052104462611400_B11","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.3390\/biom13101434","article-title":"Research progress on the structural and functional roles of hnRNPs in muscle development","volume":"13","author":"Li","year":"2023","journal-title":"Biomolecules"},{"key":"2026052104462611400_B12","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/s41420-024-02198-7","article-title":"Regulation of HNRNP family by post-translational modifications in cancer","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Discov."},{"key":"2026052104462611400_B13","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/imm.13846","article-title":"hnRNPs in antiviral innate immunity","volume":"173","author":"Maceratessi","year":"2024","journal-title":"Immunology"},{"key":"2026052104462611400_B14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3390\/cells8010062","article-title":"New insights into the interplay between non-coding RNAs and RNA-binding protein HnRNPK in regulating cellular functions","volume":"8","author":"Xu","year":"2019","journal-title":"Cells"},{"key":"2026052104462611400_B15","doi-asserted-by":"publisher","first-page":"e183697","DOI":"10.1172\/JCI183697","article-title":"The tumor suppressor HNRNPK induces p53-dependent nucleolar stress to drive ribosomopathies","volume":"135","author":"Aguilar-Garrido","year":"2025","journal-title":"J. Clin. Invest."},{"key":"2026052104462611400_B16","doi-asserted-by":"publisher","first-page":"102670","DOI":"10.1016\/j.jbc.2022.102670","article-title":"Mechanistic insights into poly(C)-binding protein hnRNP K resolving i-motif DNA secondary structures","volume":"298","author":"Wu","year":"2022","journal-title":"J. Biol. Chem."},{"key":"2026052104462611400_B17","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.cell.2024.12.004","article-title":"A biophysical basis for the spreading behavior and limited diffusion of Xist","volume":"188","author":"Ding","year":"2025","journal-title":"Cell"},{"key":"2026052104462611400_B18","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/35060131","article-title":"ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation","volume":"3","author":"Habelhah","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"2026052104462611400_B19","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.3390\/ijms26031356","article-title":"Structural characteristics and properties of the RNA-binding protein hnRNPK at multiple physical states","volume":"26","author":"Le","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026052104462611400_B20","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41419-022-05239-0","article-title":"Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1\u03b1\u2013glycolysis axis","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"key":"2026052104462611400_B21","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s13578-024-01284-8","article-title":"SOX2 interacts with hnRNPK to modulate alternative splicing in mouse embryonic stem cells","volume":"14","author":"Huang","year":"2024","journal-title":"Cell Biosci."},{"key":"2026052104462611400_B22","doi-asserted-by":"publisher","first-page":"4198","DOI":"10.1038\/s41467-019-12238-x","article-title":"HNRNPK maintains epidermal progenitor function through transcription of proliferation genes and degrading differentiation promoting mRNAs","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"2026052104462611400_B23","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/stem.2937","article-title":"LncRNA-OG promotes the osteogenic differentiation of bone marrow-derived mesenchymal stem cells under the regulation of hnRNPK","volume":"37","author":"Tang","year":"2019","journal-title":"Stem Cells"},{"key":"2026052104462611400_B24","doi-asserted-by":"publisher","first-page":"180239","DOI":"10.1098\/rsob.180239","article-title":"Post-translational modification control of RNA-binding protein hnRNPK function","volume":"9","author":"Xu","year":"2019","journal-title":"Open Biol."},{"key":"2026052104462611400_B25","doi-asserted-by":"publisher","first-page":"100198","DOI":"10.1016\/j.cellin.2024.100198","article-title":"The methyltransferase SETD3 regulates mRNA alternative splicing through interacting with hnRNPK","volume":"3","author":"Kong","year":"2024","journal-title":"Cell Insight"},{"key":"2026052104462611400_B26","first-page":"473","article-title":"ERK1\/2-mediated cytoplasmic accumulation of hnRNPK antagonizes TRAIL-induced apoptosis through upregulation of XIAP in H1299 cells","volume":"30","author":"Huang","year":"2017","journal-title":"Biomed. Environ. Sci."},{"key":"2026052104462611400_B27","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1261\/rna.042788.113","article-title":"Translation control of TAK1 mRNA by hnRNP K modulates LPS-induced macrophage activation","volume":"20","author":"Liepelt","year":"2014","journal-title":"RNA"},{"key":"2026052104462611400_B28","doi-asserted-by":"publisher","first-page":"54599","DOI":"10.1074\/jbc.M406753200","article-title":"Heterogeneous nuclear ribonucleoprotein K enhances insulin-induced expression of mitochondrial UCP2 protein","volume":"279","author":"Ostrowski","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2026052104462611400_B29","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1074\/mcp.M600134-MCP200","article-title":"Reconstructing the regulatory kinase pathways of myogenesis from phosphopeptide data","volume":"5","author":"Puente","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"2026052104462611400_B30","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1093\/nar\/gkz1176","article-title":"The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis","volume":"48","author":"Nguyen","year":"2020","journal-title":"Nucleic. Acids. Res."},{"key":"2026052104462611400_B31","doi-asserted-by":"publisher","first-page":"e1004573","DOI":"10.1371\/journal.ppat.1004573","article-title":"Identification of HNRNPK as regulator of hepatitis C virus particle production","volume":"11","author":"Poenisch","year":"2015","journal-title":"PLoS Pathog."},{"key":"2026052104462611400_B32","doi-asserted-by":"publisher","first-page":"6823","DOI":"10.1074\/jbc.M609554200","article-title":"Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1","volume":"282","author":"Tanno","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2026052104462611400_B33","doi-asserted-by":"publisher","first-page":"e65104","DOI":"10.7554\/eLife.65104","article-title":"Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function","volume":"10","author":"Haward","year":"2021","journal-title":"Elife"},{"key":"2026052104462611400_B34","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1002\/pmic.200500632","article-title":"Landscape of the hnRNP K protein\u2013protein interactome","volume":"6","author":"Mikula","year":"2006","journal-title":"Proteomics"},{"key":"2026052104462611400_B35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s42003-023-04457-2","article-title":"Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer","volume":"6","author":"Zhou","year":"2023","journal-title":"Commun. Biol."},{"key":"2026052104462611400_B36","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1186\/s12935-019-1020-x","article-title":"hnRNPK promotes gastric tumorigenesis through regulating CD44E alternative splicing","volume":"19","author":"Peng","year":"2019","journal-title":"Cancer Cell Int."},{"key":"2026052104462611400_B37","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.molcel.2017.11.013","article-title":"hnRNPK recruits PCGF3\/5-PRC1 to the Xist RNA B-repeat to establish Polycomb-mediated chromosomal silencing","volume":"68","author":"Pintacuda","year":"2017","journal-title":"Mol. Cell"},{"key":"2026052104462611400_B38","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/hmg\/ddae173","article-title":"Recruitment of chromatin remodelers by XIST B-repeat region is variably dependent on HNRNPK","volume":"34","author":"Navarro-Cobos","year":"2025","journal-title":"Hum. Mol. Genet."},{"key":"2026052104462611400_B39","doi-asserted-by":"publisher","first-page":"11626","DOI":"10.1093\/nar\/gkaa814","article-title":"SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies","volume":"48","author":"Toki","year":"2020","journal-title":"Nucleic. Acids. Res."},{"key":"2026052104462611400_B40","doi-asserted-by":"publisher","first-page":"12247","DOI":"10.1074\/jbc.RA119.011870","article-title":"PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions","volume":"295","author":"Ishii","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2026052104462611400_B41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.celrep.2012.02.001","article-title":"Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins","volume":"1","author":"Huelga","year":"2012","journal-title":"Cell Rep."},{"key":"2026052104462611400_B42","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/nsmb.1838","article-title":"iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution","volume":"17","author":"Konig","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2026052104462611400_B43","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13578-022-00849-9","article-title":"LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer","volume":"12","author":"Wang","year":"2022","journal-title":"Cell Biosci."},{"key":"2026052104462611400_B44","doi-asserted-by":"publisher","first-page":"220","DOI":"10.5483\/BMBRep.2017.50.4.024","article-title":"hnRNPK-regulated PTOV1-AS1 modulates heme oxygenase-1 expression via miR-1207-5p","volume":"50","author":"Shin","year":"2017","journal-title":"BMB Rep"},{"key":"2026052104462611400_B45","doi-asserted-by":"publisher","first-page":"e2105775","DOI":"10.1002\/advs.202105775","article-title":"Single-cell RNA sequencing reveals heterogeneity of Myf5-derived cells and altered myogenic fate in the absence of SRSF2","volume":"9","author":"Guo","year":"2022","journal-title":"Adv. Sci. (Weinh)"},{"key":"2026052104462611400_B46","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.devcel.2020.05.006","article-title":"Dek modulates global intron retention during muscle stem cells quiescence exit","volume":"53","author":"Yue","year":"2020","journal-title":"Dev. Cell"},{"key":"2026052104462611400_B47","doi-asserted-by":"publisher","first-page":"101062","DOI":"10.1016\/j.gendis.2023.06.031","article-title":"Deletion of heterogeneous nuclear ribonucleoprotein K in satellite cells leads to inhibited skeletal muscle regeneration in mice","volume":"11","author":"Xu","year":"2024","journal-title":"Genes Dis."},{"key":"2026052104462611400_B48","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1016\/j.jprot.2012.01.013","article-title":"Differential proteome and transcriptome analysis of porcine skeletal muscle during development","volume":"75","author":"Xu","year":"2012","journal-title":"J. Proteomics"},{"key":"2026052104462611400_B49","doi-asserted-by":"publisher","first-page":"4236","DOI":"10.1002\/pmic.200701101","article-title":"In vivo proteome dynamics during early bovine myogenesis","volume":"8","author":"Chaze","year":"2008","journal-title":"Proteomics"},{"key":"2026052104462611400_B50","doi-asserted-by":"publisher","first-page":"350","DOI":"10.5483\/BMBRep.2018.51.7.043","article-title":"The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts","volume":"51","author":"Xu","year":"2018","journal-title":"BMB Rep."},{"key":"2026052104462611400_B51","doi-asserted-by":"publisher","first-page":"1484102","DOI":"10.3389\/fvets.2024.1484102","article-title":"Transcriptome analysis reveals the regulatory mechanism of myofiber development in male and female black Muscovy duck at different ages","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Vet. Sci."},{"key":"2026052104462611400_B52","doi-asserted-by":"publisher","first-page":"e27192","DOI":"10.7554\/eLife.27192","article-title":"Extensive alternative splicing transitions during postnatal skeletal muscle development are required for calcium handling functions","volume":"6","author":"Brinegar","year":"2017","journal-title":"Elife"},{"key":"2026052104462611400_B53","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13395-025-00393-3","article-title":"The Paradox of hnRNPK: both absence and excess impair skeletal muscle function in mice","volume":"15","author":"Xu","year":"2025","journal-title":"Skeletal Muscle"},{"key":"2026052104462611400_B54","doi-asserted-by":"publisher","first-page":"e49874","DOI":"10.7554\/eLife.49874","article-title":"Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria","volume":"8","author":"Ubaida-Mohien","year":"2019","journal-title":"Elife"},{"key":"2026052104462611400_B55","doi-asserted-by":"publisher","first-page":"e13042","DOI":"10.1111\/acel.13042","article-title":"Demethylation and derepression of genomic retroelements in the skeletal muscles of aged mice","volume":"18","author":"Min","year":"2019","journal-title":"Aging Cell"},{"key":"2026052104462611400_B56","doi-asserted-by":"publisher","first-page":"113815","DOI":"10.1016\/j.expneurol.2021.113815","article-title":"Transcriptome analysis using patient iPSC-derived skeletal myocytes: Bet1L as a new molecule possibly linked to neuromuscular junction degeneration in ALS","volume":"345","author":"Lynch","year":"2021","journal-title":"Exp. Neurol."},{"key":"2026052104462611400_B57","doi-asserted-by":"publisher","first-page":"e47468","DOI":"10.15252\/embr.201847468","article-title":"Myogenin promoter-associated lncRNA Myoparr is essential for myogenic differentiation","volume":"20","author":"Hitachi","year":"2019","journal-title":"EMBO Rep."},{"key":"2026052104462611400_B58","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/ijms23010108","article-title":"Myoparr-associated and -independent multiple roles of heterogeneous nuclear ribonucleoprotein K during skeletal muscle cell differentiation","volume":"23","author":"Hitachi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026052104462611400_B59","doi-asserted-by":"publisher","first-page":"104172","DOI":"10.1016\/j.dib.2019.104172","article-title":"Data describing the effects of depletion of Myoparr, myogenin, Ddx17, and hnRNPK in differentiating C2C12 cells","volume":"25","author":"Hitachi","year":"2019","journal-title":"Data Brief"},{"key":"2026052104462611400_B60","doi-asserted-by":"publisher","first-page":"5787","DOI":"10.1038\/s41467-019-13598-0","article-title":"MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat. Commun."},{"key":"2026052104462611400_B61","doi-asserted-by":"publisher","first-page":"146625","DOI":"10.1016\/j.ijbiomac.2025.146625","article-title":"Study on the mechanism of LNC004268 regulating sheep myoblast proliferation and differentiation through hnRNPK-CNOT2 axis","volume":"321","author":"Song","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"2026052104462611400_B62","doi-asserted-by":"publisher","first-page":"112160","DOI":"10.1016\/j.cellsig.2025.112160","article-title":"Unraveling the hnRNPK\/miR-133a-3p\/UCP2 axis: a novel regulatory circuit governing porcine skeletal muscle satellite cell fate","volume":"136","author":"Xu","year":"2025","journal-title":"Cell. Signal."},{"key":"2026052104462611400_B63","doi-asserted-by":"publisher","first-page":"e70024","DOI":"10.1096\/fba.2025-00007","article-title":"Impact of acute endurance exercise on alternative splicing in skeletal muscle","volume":"7","author":"Ahn","year":"2025","journal-title":"FASEB Bioadv."},{"key":"2026052104462611400_B64","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/onc.2017.314","article-title":"MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression","volume":"37","author":"Liu","year":"2018","journal-title":"Oncogene"},{"key":"2026052104462611400_B65","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.devcel.2014.08.025","article-title":"RBM24 is a major regulator of muscle-specific alternative splicing","volume":"31","author":"Yang","year":"2014","journal-title":"Dev. Cell"},{"key":"2026052104462611400_B66","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/nature11922","article-title":"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS","volume":"495","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"2026052104462611400_B67","doi-asserted-by":"publisher","first-page":"8881","DOI":"10.1523\/JNEUROSCI.0455-22.2022","article-title":"The SYNGAP1 3\u2032UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK","volume":"42","author":"Yokoi","year":"2022","journal-title":"J. Neurosci."},{"key":"2026052104462611400_B68","doi-asserted-by":"publisher","first-page":"7617","DOI":"10.1007\/s00018-021-03992-7","article-title":"Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN","volume":"78","author":"Yao","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"2026052104462611400_B69","doi-asserted-by":"publisher","first-page":"e106357","DOI":"10.15252\/embj.2020106357","article-title":"High-resolution mapping of function and protein binding in an RNA nuclear enrichment sequence","volume":"40","author":"Lubelsky","year":"2021","journal-title":"EMBO J."},{"key":"2026052104462611400_B70","doi-asserted-by":"publisher","first-page":"e1011608","DOI":"10.1371\/journal.pgen.1011608","article-title":"Epigenome and transcriptome changes in KMT2D-related Kabuki syndrome type 1 iPSCs, neuronal progenitors and cortical neurons","volume":"21","author":"Cuvertino","year":"2025","journal-title":"PLos Genet."},{"key":"2026052104462611400_B71","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1016\/j.ajhg.2025.07.001","article-title":"An HNRNPK-specific DNA methylation signature makes sense of missense variants and expands the phenotypic spectrum of Au-Kline syndrome","volume":"112","author":"Choufani","year":"2025","journal-title":"Am. J. Hum. Genet."},{"key":"2026052104462611400_B72","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/ajmg.a.61079","article-title":"Okamoto syndrome has features overlapping with Au-Kline syndrome and is caused by HNRNPK mutation","volume":"179","author":"Okamoto","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"2026052104462611400_B73","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1080\/15548627.2019.1586246","article-title":"METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia\/reoxygenation-treated cardiomyocytes","volume":"15","author":"Song","year":"2019","journal-title":"Autophagy"},{"key":"2026052104462611400_B74","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1038\/s41374-019-0243-8","article-title":"Mitochondrial localization of PABPN1 in oculopharyngeal muscular dystrophy","volume":"99","author":"Doki","year":"2019","journal-title":"Lab. Invest."},{"key":"2026052104462611400_B75","doi-asserted-by":"publisher","first-page":"e2400152","DOI":"10.1002\/adbi.202400152","article-title":"Loss of HNRNPU in skeletal muscle increases intramuscular infiltration of Ly6C positive cells, leading to muscle atrophy through activation of NF-kappaB signaling","volume":"8","author":"Lee","year":"2024","journal-title":"Adv. Biol. (Weinh)"},{"key":"2026052104462611400_B76","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1165\/rcmb.2020-0449OC","article-title":"RANKL mediates muscle atrophy and dysfunction in a cigarette smoke-induced model of chronic obstructive pulmonary disease","volume":"64","author":"Xiong","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2026052104462611400_B77","doi-asserted-by":"publisher","first-page":"2063179","DOI":"10.1155\/2018\/2063179","article-title":"Role of oxidative stress as key regulator of muscle wasting during cachexia","volume":"2018","author":"Abrigo","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"2026052104462611400_B78","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00415-011-6062-5","article-title":"A systematic review of quality of life in adults with muscle disease","volume":"258","author":"Graham","year":"2011","journal-title":"J. Neurol."},{"key":"2026052104462611400_B79","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1002\/jcp.29186","article-title":"The emerging roles of hnRNPK","volume":"235","author":"Wang","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"2026052104462611400_B80","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00401-022-02471-y","article-title":"HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS","volume":"144","author":"Braems","year":"2022","journal-title":"Acta Neuropathol."},{"key":"2026052104462611400_B81","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3389\/fnins.2018.00326","article-title":"Linking hnRNP function to ALS and FTD pathology","volume":"12","author":"Purice","year":"2018","journal-title":"Front Neurosci."},{"key":"2026052104462611400_B82","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13024-023-00642-3","article-title":"Translation dysregulation in neurodegenerative diseases: a focus on ALS","volume":"18","author":"Wang","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"2026052104462611400_B83","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2025.02.021","article-title":"Overexpression of hnRNPK and inhibition of cytoplasmic translocation ameliorate lipid disorder in doxorubicin-induced cardiomyopathy via PINK1\/Parkin-mediated mitophagy","volume":"231","author":"Xu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"2026052104462611400_B84","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.exphem.2022.01.004","article-title":"hnRNPK\/Beclin1 signaling regulates autophagy to promote imatinib resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia cells","volume":"108","author":"Zhang","year":"2022","journal-title":"Exp. Hematol."},{"key":"2026052104462611400_B85","first-page":"69","article-title":"Impaired regeneration in dystrophic muscle\u2014new target for therapy","volume":"13","author":"Yanay","year":"2020","journal-title":"Front Mol. Neurosci."},{"key":"2026052104462611400_B86","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1093\/brain\/awae323","article-title":"Biological biomarkers in muscle diseases relevant for follow-up and evaluation of treatment","volume":"148","author":"Stemmerik","year":"2025","journal-title":"Brain"},{"key":"2026052104462611400_B87","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2217\/bmm.12.96","article-title":"Proteomic identification of biomarkers of skeletal muscle disorders","volume":"7","author":"Ohlendieck","year":"2013","journal-title":"Biomark Med."},{"key":"2026052104462611400_B88","doi-asserted-by":"publisher","first-page":"e13752","DOI":"10.1002\/jcsm.13752","article-title":"snRNA-seq and spatial transcriptome reveal cell\u2013cell crosstalk mediated metabolic regulation in porcine skeletal muscle","volume":"16","author":"Guo","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"2026052104462611400_B89","doi-asserted-by":"publisher","first-page":"8346","DOI":"10.3390\/ijms21218346","article-title":"Stress-specific spatiotemporal responses of RNA-binding proteins in human stem-cell\u2013derived motor neurons","volume":"21","author":"Harley","year":"2020","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biochemical Society Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/54\/5\/571\/988157\/bst-2025-0557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article-pdf\/54\/5\/571\/988157\/bst-2025-0557.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:46:32Z","timestamp":1779353192000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemsoctrans\/article\/54\/5\/571\/237577\/RNA-binding-protein-hnRNPK-a-multifunctional"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":89,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,21]]},"published-print":{"date-parts":[[2026,5,27]]}},"URL":"https:\/\/doi.org\/10.1042\/bst20250557","relation":{},"ISSN":["0300-5127","1470-8752"],"issn-type":[{"value":"0300-5127","type":"print"},{"value":"1470-8752","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,5]]}}}