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Therefore, the expression, processing, and signalling activities of this neurotrophin, which is reliant upon TrkB and p75NTR receptors, have been well characterised in both health and disease. This review summarises the latest findings on BDNF dysregulation in neuropathologies. Indeed, across diseases of both the central and peripheral nervous systems, BDNF signalling is frequently disrupted, contributing to neuronal dysfunction and degeneration. Consequently, through direct or indirect enhancement of its expression and\/or function, BDNF has proved to be a promising therapeutic target across many neurological conditions. However, the complexity of its regulation and interaction with several different receptors underpins the need for further research to deepen our understanding of BDNF disruption in neuropathologies and to achieve its therapeutic potential.<\/jats:p>","DOI":"10.1042\/bst20253079","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:38:28Z","timestamp":1771864708000},"page":"211-227","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Disruption of BDNF signalling in neuropathologies"],"prefix":"10.1042","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3150-4453","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Paulo-Ramos","sequence":"first","affiliation":[{"name":"1Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7103-5513","authenticated-orcid":false,"given":"Elena\u00a0R.","family":"Rhymes","sequence":"additional","affiliation":[{"name":"1Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-7216","authenticated-orcid":false,"given":"David","family":"Villarroel-Campos","sequence":"additional","affiliation":[{"name":"1Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, U.K."},{"name":"2UK Dementia Research Institute, University College London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-9045","authenticated-orcid":false,"given":"James\u00a0N.","family":"Sleigh","sequence":"additional","affiliation":[{"name":"1Department of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, U.K."},{"name":"2UK Dementia Research Institute, University College London, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"2026040112215780600_B1","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Arch. 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