{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:16:54Z","timestamp":1788869814024,"version":"build-2803163510"},"reference-count":118,"publisher":"Portland Press Ltd.","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","award":["26-23223S"],"award-info":[{"award-number":["26-23223S"]}]},{"name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","award":["LM2023050"],"award-info":[{"award-number":["LM2023050"]}]},{"name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","award":["CZ.02.1.01\/0.0\/0.0\/18_046\/0016045"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/18_046\/0016045"]}]}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cristae are mitochondrial subcompartments that give the organelle its distinctive appearance. More significantly, mitochondria are the proverbial powerhouses as cristae house the molecular machinery underlying cellular respiration, a process that converts carbon sources into ATP by chemiosmosis. The form of cristae is invariably connected to their bioenergetic function. Here, we review our current understanding of the molecules underpinning crista formation. Not surprisingly, respiratory chain multiprotein complexes are involved in crista formation, with F1FO-ATP synthase dimers being eminent membrane sculptors. But crista formation also requires factors that are not directly part of the respiratory chain. The most ancient is the MICOS complex, which delineates the subcompartment and acts as a hub for crista biogenesis. The mitochondrial inner membrane (IM), from which cristae emerge, is remodelled by different dynamin-related proteins in animals and fungi. Cardiolipin is an integral component of the membranous fabric of the IM. To begin to grasp general design principles underlying crista formation, we synthesize findings from canonical animal and yeast experimental models with those from diverse protists and other eukaryotes. However, how these molecules are orchestrated during crista formation remains a hidden piece in our understanding of how cells differentiate in specialized forms. We highlight the few knowns about crista formation in a handful of organisms to guide research into the many unknowns about how complex subcompartments represented by mitochondrial cristae are formed.<\/jats:p>","DOI":"10.1042\/bst20260167","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:11:56Z","timestamp":1787818316000},"page":"1155-1167","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The molecular mechanisms of crista formation: how mitochondria give themselves breathing room"],"prefix":"10.1042","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3840-7283","authenticated-orcid":false,"given":"Lilia","family":"Colina-Tenorio","sequence":"first","affiliation":[{"name":"1Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, \u010cesk\u00e9 Bud\u011bjovice, Czechia"},{"name":"2Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-7190","authenticated-orcid":false,"given":"Martina","family":"Bohuslavov\u00e1","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, \u010cesk\u00e9 Bud\u011bjovice, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-4412","authenticated-orcid":false,"given":"Alexander\u00a0W.","family":"Bruce","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, \u010cesk\u00e9 Bud\u011bjovice, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6678-1618","authenticated-orcid":false,"given":"Hassan","family":"Hashimi","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology and Genetics, Faculty of Science, University of South Bohemia, \u010cesk\u00e9 Bud\u011bjovice, Czechia"},{"name":"2Institute of Parasitology, Biology Centre, Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026082704114985800_B1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/ar.1091140304","article-title":"The fine structure of mitochondria","volume":"114","author":"Palade","year":"1952","journal-title":"Anat. 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