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After being injected with CCl<jats:sub>4<\/jats:sub> (carbon tetrachloride), mice were injected with syngenic BM\u2010derived MSCs or normal saline. Oxidative stress activity of the MSCs was determined by the analysis of ROS (reactive oxygen species) and SOD (superoxide dismutase) activity. In addition, cytoprotective genes of the liver tissue were assessed by real\u2010time PCR and ARE (antioxidant\u2010response element) reporter assay. Up\u2010regulated ROS of CCl<jats:sub>4<\/jats:sub>\u2010treated liver cells was attenuated by co\u2010culturing with MSCs. Suppression of SOD by adding an SOD inhibitor decreased the effect of MSCs on injured liver cells. MSCs significantly increased SOD activity and inhibited ROS production in the injured liver. The gene expression levels of <jats:italic>Hmox\u20101<\/jats:italic> (haem oxygenase\u20101), <jats:italic>BI\u20101<\/jats:italic> (Bax inhibitor\u20101), <jats:italic>HGF<\/jats:italic> (hepatocyte growth factor), <jats:italic>GST<\/jats:italic> (glutathione transferase) and <jats:italic>Nrf2<\/jats:italic> (nuclear factor\u2010erythoid 2 p45 subunit\u2010related factor 20), attenuated by CCl<jats:sub>4<\/jats:sub>, were increased up to basal levels after MSC transplantation. In addition, MSCs induced an ARE, shown by luciferase activity, which represented a cytoprotective response in the injured liver. Evidence of a new cytoprotective effect is shown in which MSCs promote an antioxidant response and supports the potential of using MSC transplantation as an effective treatment modality for liver disease.<\/jats:p>","DOI":"10.1042\/cbi20110634","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T09:11:55Z","timestamp":1349687515000},"page":"1267-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Mesenchymal stem cells restore CCl<sub>4<\/sub>\u2010induced liver injury by an antioxidative 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