{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:06:07Z","timestamp":1759482367883},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,3,1]]},"abstract":"<jats:p>1. A comparison has been made between alkaline mannitol diuresis and alkaline glucose diuresis in the treatment of salicylate poisoning during an 8 hr period.<\/jats:p>\n               <jats:p>2. Mannitol gave a higher rate of urine flow, but there was no significant difference in the rate of salicylate excretion.<\/jats:p>\n               <jats:p>3. Serum levels of sodium, potassium and calcium fell in both groups, mainly during the first 2 hr. The mean fall in serum sodium was greater (21\u00b74 mEq\/l compared with 10\u00b70 mEq\/l) and that in serum potassium less (0\u00b76 mEq\/l compared with 1\u00b75 mEq\/l) in patients who received mannitol than in those who did not.<\/jats:p>\n               <jats:p>4. All serum electrolyte values had returned to normal within 24 hr of the end of the treatment period.<\/jats:p>\n               <jats:p>5. Acid\u2014base changes occurring during treatment are described.<\/jats:p>\n               <jats:p>6. No adverse clinical features were seen in either treatment group.<\/jats:p>\n               <jats:p>7. Syrup of ipecacuanha was used to induce emesis. The mean recovery of salicylate in the vomitus was 38% of the apparent total ingested. The variability in recovery (0\u201381%) was not related to the delay between ingestion and vomiting.<\/jats:p>\n               <jats:p>8. It is concluded that mannitol does not increase the excretion of salicylate. It maintains good urinary excretion, thereby increasing the safety of the procedure. It is associated with a smaller fall in serum potassium and permits rapid removal of salicylate for a smaller rise in serum pH than does forced alkaline diuresis alone.<\/jats:p>","DOI":"10.1042\/cs0380327","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:14:19Z","timestamp":1438942459000},"page":"327-337","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Treatment of Salicylate Poisoning Using Mannitol and Forced Alkaline Diuresis"],"prefix":"10.1042","volume":"38","author":[{"given":"K.","family":"Prowse","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Birmingham, Queen Elizabeth Medical Centre, Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pain","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Birmingham, Queen Elizabeth Medical Centre, Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Marston","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Birmingham, Queen Elizabeth Medical Centre, Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Cumming","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Birmingham, Queen Elizabeth Medical Centre, Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/38\/3\/327\/749789\/cs0380327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/38\/3\/327\/749789\/cs0380327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T12:34:16Z","timestamp":1638448456000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/38\/3\/327\/69683\/The-Treatment-of-Salicylate-Poisoning-Using"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0380327","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1970,3,1]]}}}