{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:43:09Z","timestamp":1771645389766,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,3,1]]},"abstract":"<jats:p>1. Ethacrynic acid reduces renal vascular resistance of the isolated dog kidney.<\/jats:p>\n               <jats:p>2. Ethacrynic acid induced natriuresis can occur despite stabilization of renal blood flow, but augmentation of blood flow increases the natriuretic response.<\/jats:p>\n               <jats:p>3. Vasodilatation and natriuresis after ethacrynic acid administration occurred together in time and were not separable. The onset and peak natriuretic and vasodilator responses frequently coincided in time.<\/jats:p>\n               <jats:p>4. Ethacrynic acid induced vasodilatation could be inhibited by loss of body fluid. The rise in resistance could be avoided by adequate volume replacement and by prevention of volume depletion.<\/jats:p>","DOI":"10.1042\/cs0380347","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:14:19Z","timestamp":1438942459000},"page":"347-357","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Vasodilator Properties of Ethacrynic Acid in the Perfused Dog Kidney"],"prefix":"10.1042","volume":"38","author":[{"given":"R. G.","family":"Dluhy","sequence":"first","affiliation":[{"name":"Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. L.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Lauler","sequence":"additional","affiliation":[{"name":"Endocrine-Metabolic Unit, Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/38\/3\/347\/749791\/cs0380347.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/38\/3\/347\/749791\/cs0380347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T12:38:07Z","timestamp":1638448687000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/38\/3\/347\/69701\/Vasodilator-Properties-of-Ethacrynic-Acid-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0380347","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1970,3,1]]}}}