{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:18Z","timestamp":1787004498897,"version":"build-2736575974"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,12,1]]},"abstract":"<jats:p>1. Total body, intracellular, and extracellular electrolyte and acid-base changes were studied following sodium nitrate-induced potassium and chloride depletion and subsequent selective chloride repletion.<\/jats:p>\n                  <jats:p>2. It was found that potassium and chloride depletion was associated with markedly decreased extracellular Na, K, Cl and water content. Intracellular Na increased, intracellular K decreased and there was a large transcellular redistribution of acid, i.e. extracellular alkalosis and intracellular acidosis ensued.<\/jats:p>\n                  <jats:p>3. Selective chloride repletion was associated with return of extracellular pH towards normal. Extracellular K and intracellular parameters showed very little change. Further chloride administration was followed by extracellular acidosis, but extracellular K remained low.<\/jats:p>\n                  <jats:p>4. There was close relationship between extracellular chloride and hydrogen ion concentrations ([Cl\u2212]e and [H+]e) and extracellular potassium and intracellular hydrogen ion ([K+]e and [H+]i) but not between any of the other parameters. The close relationship between [H+]e and [Cl\u2212]e may be explained by the chemical relationship between [H+]e, Pco2, and [HCO3\u2212]e and empirical relationships between [Cl\u2212]e and [HCO3\u2212]e, and Pco2 and [HCO3\u2212]e.<\/jats:p>","DOI":"10.1042\/cs0390731","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:23:04Z","timestamp":1438928584000},"page":"731-745","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Relationships between Potassium, Chloride, Intracellular and Extracellular pH in Dogs"],"prefix":"10.1042","volume":"39","author":[{"given":"A. F.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Medicine, U.C.L.A. School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. H.","family":"Simmons","sequence":"additional","affiliation":[{"name":"Department of Medicine, U.C.L.A. School of Medicine, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/39\/6\/731\/750112\/cs0390731.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/39\/6\/731\/750112\/cs0390731.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T08:46:29Z","timestamp":1638434789000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/39\/6\/731\/69857\/Relationships-between-Potassium-Chloride"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1970,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0390731","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1970,12,1]]}}}