{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:26:07Z","timestamp":1779114367379,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,1,1]]},"abstract":"<jats:p>1. The metabolism of radioactive vitamin D3 has been studied in individuals low or deficient in vitamin D (group I) and in vitamin D treated subjects (group II).<\/jats:p>\n               <jats:p>2. In group I there was a smaller serum pool of vitamin D, turning over more rapidly than in group II. The principal metabolite, peak IV, appeared more rapidly in the serum of group I; the level of radioactivity attained in this and in the more polar metabolites, peak V and VI, was also higher than in group II. Peak VI was the major radioactive component in serum after 100 days.<\/jats:p>\n               <jats:p>3. Vitamin D treatment of individuals in group I converted the pattern of metabolism of radioactive vitamin D3 to that characteristic of group II. This effect was observed in healthy individuals and in patients with vitamin D deficiency or with chronic renal failure.<\/jats:p>\n               <jats:p>4. The metabolic disposal of vitamin D entering the body appears to be determined by the state of vitamin D nutrition in the individual. Reported changes of vitamin D metabolism in diseases such as renal failure could be determined by the nutritional state of the patients studied rather than by the primary disease.<\/jats:p>","DOI":"10.1042\/cs0400039","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:25:02Z","timestamp":1438943102000},"page":"39-53","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["The Metabolism of Isotopically Labelled Vitamin D3 in Man: The Influence of the State of Vitamin D Nutrition"],"prefix":"10.1042","volume":"40","author":[{"given":"E. Barbara","family":"Mawer","sequence":"first","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Lumb","sequence":"additional","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Stanbury","sequence":"additional","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/40\/1\/39\/738072\/cs0400039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/40\/1\/39\/738072\/cs0400039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T10:32:05Z","timestamp":1638441125000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/40\/1\/39\/69323\/The-Metabolism-of-Isotopically-Labelled-Vitamin-D3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1971,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0400039","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1971,1,1]]}}}