{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:00:29Z","timestamp":1715544029164},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,3,1]]},"abstract":"<jats:p>1. Several phenomena observed in man during acute exposure to high altitude could be explained in part by a decrease in compliance of systemic capacitance vessels.<\/jats:p>\n               <jats:p>2. Serial measurements of forearm venous compliance were made with a water-filled plethysmograph in healthy men during a 24 h stay at 4300 m.<\/jats:p>\n               <jats:p>3. A decrease in venous compliance (increase in venous tone) occurred in all subjects and averaged 17\u00b70 \u00b1 6\u00b72% (SEM).<\/jats:p>\n               <jats:p>4. In seven normal men during 1 week at 4300 m, a decrease in venous compliance again occurred in all subjects and was sustained throughout the 1 week period. There was also a rise in forearm blood flow and a fall in forearm vascular resistance. Increases in urinary excretion of noradrenaline and vanilmandelic acid suggested that these responses are mediated by the sympathetic nervous system.<\/jats:p>\n               <jats:p>5. Acute laboratory studies suggest that the response is primarily triggered by hypocapnia and potentiated by hypoxia; it cannot be duplicated by hyperventilation or by mild hypoxia in the absence of hypocapnia.<\/jats:p>\n               <jats:p>6. This decrease in systemic venous compliance may play an important role in the increased central blood volume and cardiac output which are seen acutely following ascent to high altitude.<\/jats:p>","DOI":"10.1042\/cs0400235","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:25:02Z","timestamp":1438943102000},"page":"235-246","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Forearm Circulation in Man at High Altitude"],"prefix":"10.1042","volume":"40","author":[{"given":"J. V.","family":"Weil","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Byrne-Quinn","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Battock","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"Grover","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Chidsey","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/40\/3\/235\/813943\/cs0400235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/40\/3\/235\/813943\/cs0400235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T12:36:50Z","timestamp":1638448610000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/40\/3\/235\/69698\/Forearm-Circulation-in-Man-at-High-Altitude"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1971,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0400235","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1971,3,1]]}}}