{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:31:57Z","timestamp":1771644717029,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,10,1]]},"abstract":"<jats:p>1. The changes of peripheral venous plasma renin concentration (PRC) induced by head-up tilting were studied in four patients with orthostatic hypotension.<\/jats:p>\n               <jats:p>2. Two of the patients had the Holmes\u2014Adie syndrome and tests of autonomic function suggested that they had an afferent block from baroreceptors with intact efferent pathways; the others had no evidence of the Holmes\u2014Adie syndrome and investigations suggested that they had interruption of efferent sympathetic pathways.<\/jats:p>\n               <jats:p>3. In the two patients in whom lesions of the afferent side of baroreceptor reflexes were suspected, a marked increase in PRC occurred with upright tilting, whereas no change in PRC occurred in the two patients thought to have an efferent sympathetic block.<\/jats:p>\n               <jats:p>4. During repeated tilting, supine blood pressure and PRC increased progressively in the two patients with suspected afferent block, but not in the two patients with suspected efferent block.<\/jats:p>\n               <jats:p>5. It is suggested that an increase in plasma renin may contribute to the supine hypertension sometimes observed in patients with orthostatic hypotension.<\/jats:p>\n               <jats:p>6. It is also suggested that renin release does not require intact autonomic reflexes although certain components of efferent sympathetic pathways, not dependent on baroreceptor reflexes, may be important.<\/jats:p>","DOI":"10.1042\/cs0410289","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:25:32Z","timestamp":1438943132000},"page":"289-299","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Plasma Renin in Idiopathic Orthostatic Hypotension: Differential Response in Subjects with Probable Afferent and Efferent Autonomic Failure"],"prefix":"10.1042","volume":"41","author":[{"given":"D. R.","family":"Love","sequence":"first","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Southern General Hospital, Glasgow"},{"name":"University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Brown","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Southern General Hospital, Glasgow"},{"name":"University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Chinn","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Southern General Hospital, Glasgow"},{"name":"University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Johnson","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Southern General Hospital, Glasgow"},{"name":"University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F.","family":"Lever","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Southern General Hospital, Glasgow"},{"name":"University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Park","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Southern General Hospital, Glasgow"},{"name":"University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I. S.","family":"Robertson","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Southern General Hospital, Glasgow"},{"name":"University Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/41\/4\/289\/753802\/cs0410289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/41\/4\/289\/753802\/cs0410289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T10:32:01Z","timestamp":1638441121000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/41\/4\/289\/69322\/Plasma-Renin-in-Idiopathic-Orthostatic-Hypotension"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1971,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0410289","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1971,10,1]]}}}