{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:31:43Z","timestamp":1790677903571,"version":"4.1.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,1,1]]},"abstract":"<jats:p>1. Elevated concentrations of immunoreactive parathyroid hormone (P.T.H.) were detected in the pre-treatment plasma samples of seven out of ten children with nutritional rickets. The three normal values occurred in an inactive case, an infant with associated kwashiorkor and a child with late onset juvenile rickets.<\/jats:p>\n               <jats:p>2. Five children, reinvestigated after 6 weeks of vitamin D treatment, showed highly significant falls in P.T.H. concentration, confirming the functional nature of the secondary hyperparathyroidism. The activity of plasma alkaline phosphatase was less consistently decreased after treatment in these cases.<\/jats:p>\n               <jats:p>3. Convincing radiological evidence of (secondary) hyperparathyroidism was not detected in the hand bones of any of the rachitic children.<\/jats:p>\n               <jats:p>4. The possible diagnostic value of plasma P.T.H. measurement in active rickets is indicated.<\/jats:p>","DOI":"10.1042\/cs0420113","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:25:42Z","timestamp":1438943142000},"page":"113-116","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Parathyroid-Hormone Concentrations in Nutritional Rickets"],"prefix":"10.1042","volume":"42","author":[{"given":"B. I.","family":"Joffe","sequence":"first","affiliation":[{"name":"Departments of Medicine and Paediatrics, University of the Witwatersrand Medical School, Johannesburg, South Africa"},{"name":"Laboratory for Endocrinological Chemistry, Bergwegziekenhuis, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. H. L.","family":"Hackeng","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Paediatrics, University of the Witwatersrand Medical School, Johannesburg, South Africa"},{"name":"Laboratory for Endocrinological Chemistry, Bergwegziekenhuis, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Seftel","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Paediatrics, University of the Witwatersrand Medical School, Johannesburg, South Africa"},{"name":"Laboratory for Endocrinological Chemistry, Bergwegziekenhuis, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. G.","family":"Hartdegen","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Paediatrics, University of the Witwatersrand Medical School, Johannesburg, South Africa"},{"name":"Laboratory for Endocrinological Chemistry, Bergwegziekenhuis, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/42\/1\/113\/750545\/cs0420113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/42\/1\/113\/750545\/cs0420113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T11:21:35Z","timestamp":1638444095000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/42\/1\/113\/69481\/Parathyroid-Hormone-Concentrations-in-Nutritional"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0420113","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1972,1,1]]}}}