{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:34:35Z","timestamp":1771626875348,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,3,1]]},"abstract":"<jats:p>1. Awake dogs with chronically implanted catheters (pulmonary artery, left atrium, aorta) and electromagnetic flow probe (main pulmonary artery) underwent five types of experiments in succession: (1) slow infusion of 0\u00b74 m-hydrochloric acid; (2) rapid infusion of 1\u00b70 m-sodium bicarbonate; (3) exposure to 30 min of hypoxia (10% O2); (4) exposure to hypoxia after arterial pH had been lowered to 7\u00b730; (5) exposure to hypoxia after pH had been increased to 7\u00b755. Intravascular pressures, pulmonary vascular resistance, cardiac output, arterial gas tension and pH were studied.<\/jats:p>\n               <jats:p>2. Acute acidosis (pH 7\u00b721) resulted in a small rise in pulmonary artery pressure, cardiac output and pulmonary vascular resistance, associated with a decrease in Pa,co2. Acute alkalosis (pH 7\u00b761) was accompanied by a small rise in pulmonary artery pressure, marked increase in cardiac output, a fall in pulmonary vascular resistance and mild elevation in Pa,co2. During acidosis hypoxia resulted in a more pronounced rise in pulmonary vascular resistance than during alkalosis (P &amp;lt; 0\u00b701).<\/jats:p>\n               <jats:p>3. The study provides evidence that in the intact, awake dog with its compensatory mechanisms acute alkalosis decreases pulmonary vascular resistance by decreasing vascular tone and\/or recruitment of pulmonary vascular channels; it diminishes the vasoconstrictive response to hypoxia; conversely, mild acidosis increases the pulmonary vascular resistance slightly and enhances vasoconstriction during hypoxia to a small extent.<\/jats:p>","DOI":"10.1042\/cs0420277","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:25:42Z","timestamp":1438943142000},"page":"277-287","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Acutely Induced Changes in Arterial pH on Pulmonary Vascular Resistance during Normoxia and Hypoxia in Awake Dogs"],"prefix":"10.1042","volume":"42","author":[{"given":"O. G.","family":"Thilenius","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Chicago, Hospitals and Clinics, Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Derenzo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Chicago, Hospitals and Clinics, Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/42\/3\/277\/738192\/cs0420277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/42\/3\/277\/738192\/cs0420277.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T10:39:16Z","timestamp":1638441556000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/42\/3\/277\/69373\/Effects-of-Acutely-Induced-Changes-in-Arterial-pH"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0420277","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1972,3,1]]}}}