{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T03:07:51Z","timestamp":1649041671773},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,7,1]]},"abstract":"<jats:p>1. We have determined the ventilatory response to CO2 inhaled in 30% oxygen (balance nitrogen) in eight normal subjects (1) before and during 4 days of 80 mg of oral frusemide daily and (2) within 55\u201375 min of 80 mg of frusemide orally.<\/jats:p>\n               <jats:p>2. Over 4 days the drug decreased serum potassium concentrations, but increased end tidal (and arterial) Pco2 and serum bicarbonate, thus inducing a mild metabolic alkalosis with an appropriate but small shift in CO2 response to the right without a significant change in the slope of the response. The CO2 response was unaltered by oral frusemide 55\u201375 min earlier.<\/jats:p>\n               <jats:p>3. This slight rise in Pco2 during 4 days of frusemide therapy contrasts with the absence of rise in Pco2 after treatment with thiazide diuretics, as reported by others.<\/jats:p>\n               <jats:p>4. We discuss possible implications of these results for the selection of an appropriate diuretic in patients with CO2 retention at various phases of their illness.<\/jats:p>","DOI":"10.1042\/cs0430047","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:05Z","timestamp":1438943165000},"page":"47-54","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Ventilatory Response to CO2 after Administration of Frusemide in Normal Man"],"prefix":"10.1042","volume":"43","author":[{"given":"H. W.","family":"Iff","sequence":"first","affiliation":[{"name":"Department of Medicine at the Royal Infirmary, University of Edinburgh, Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Flenley","sequence":"additional","affiliation":[{"name":"Department of Medicine at the Royal Infirmary, University of Edinburgh, Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/1\/47\/814602\/cs0430047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/1\/47\/814602\/cs0430047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T13:59:25Z","timestamp":1638453565000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/43\/1\/47\/69921\/The-Ventilatory-Response-to-CO2-after"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0430047","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1972,7,1]]}}}