{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:27:31Z","timestamp":1759541251920},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,7,1]]},"abstract":"<jats:p>1. Simultaneous measurements of exchangeable Na+, exchangeable K+, extracellular fluid volume and total body water, with 24Na, 43K, 77Br and 3H2O, were carried out in patients with adrenocortical insufficiency due to pituitary ablation performed 1\u20133 months previously.<\/jats:p>\n               <jats:p>2. The first group of five patients was studied before and after withdrawal of maintenance prednisone (2\u00b75 mg three times daily, orally). The effects of glucocorticoid withdrawal were: (a) an increase in intracellular water (all cases) and a decrease in the extracellular fluid volume (four cases) irrespective of any change in serum Na+ concentration; (b) an increase in residual (\u2018intracellular\u2019) Na+ in all cases which was matched by a loss of extracellular Na+, so that total body Na+ remained unchanged, and (c) the cortisol deficiency clinical syndrome. Exchangeable K+ remained unchanged.<\/jats:p>\n               <jats:p>3. Similar measurements were obtained with two further patients during the corticosteroid withdrawal period, throughout which they were kept on a maintenance dose of deoxycorticosterone acetate, 1\u00b70 mg twice daily sublingually. Neither the above biochemical changes nor the cortisol deficiency syndrome developed.<\/jats:p>\n               <jats:p>4. The shift into the cells of water and Na+ may depend on the same defect caused by glucocorticoid deficiency, and may be the cause of the cortisol deficiency syndrome.<\/jats:p>","DOI":"10.1042\/cs0430079","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:05Z","timestamp":1438943165000},"page":"79-90","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of Glucocorticoid Withdrawal on Body Water and Electrolytes in Hypopituitary Patients with Adrenocortical Insufficiency as Investigated with 77Br, 43K, 24Na and 3H2O"],"prefix":"10.1042","volume":"43","author":[{"given":"F.","family":"Skrabal","sequence":"first","affiliation":[{"name":"Departments of Medicine and Medical Physics, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Arnot","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Medical Physics, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Joplin","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Medical Physics, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. R.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Medical Physics, Royal Postgraduate Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/1\/79\/814706\/cs0430079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/1\/79\/814706\/cs0430079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T14:31:53Z","timestamp":1638455513000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/43\/1\/79\/69961\/The-Effect-of-Glucocorticoid-Withdrawal-on-Body"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0430079","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1972,7,1]]}}}