{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T11:14:43Z","timestamp":1699787683960},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,8,1]]},"abstract":"<jats:p>1. An intravenous infusion of calcitonin produced a sudden increase of plasma radioactivity after intravenous administration of 47Ca in man.<\/jats:p>\n               <jats:p>2. This effect was noted a few minutes before the well-known decrease of plasma calcium concentration.<\/jats:p>\n               <jats:p>3. A mathematical evaluation of this phenomenon demonstrated that: (a) it was significant in normal subjects, provided patients were given calcitonin 60\u2013360 min after the intravenous injection of 47Ca; (b) it was generally not significant in patients with senile osteoporosis or osteomalacia; (c) it was particularly evident in patients with generalized Paget's disease or multiple myeloma.<\/jats:p>\n               <jats:p>4. Surface measurements performed on soft tissues and bone demonstrated a transient, simultaneous decrease of 47Ca radioactivity from bone.<\/jats:p>\n               <jats:p>5. The increase in plasma radioactivity implies a shift of 47Ca from reservoirs with high specific radioactivity, possibly bone cells, to the circulation.<\/jats:p>\n               <jats:p>6. According to these data two different mechanisms of action of calcitonin could be considered: an early effect on bone cells producing a shift of calcium to the circulation, and the well-known later hypocalcaemic effect through diminution of bone resorption.<\/jats:p>","DOI":"10.1042\/cs0430171","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:05Z","timestamp":1438943165000},"page":"171-180","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Initial Increase of Plasma Radioactive Calcium after Intravenous Injection of Calcitonin in Man"],"prefix":"10.1042","volume":"43","author":[{"given":"A.","family":"Caniggia","sequence":"first","affiliation":[{"name":"Institute of Medical Semeiotics, University of Siena, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gennari","sequence":"additional","affiliation":[{"name":"Institute of Medical Semeiotics, University of Siena, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Piantelli","sequence":"additional","affiliation":[{"name":"Institute of Physics, University of Siena, Siena, Italy"},{"name":"Institute of Medical Semeiotics, University of Siena, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vattimo","sequence":"additional","affiliation":[{"name":"Institute of Medical Semeiotics, University of Siena, Siena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/2\/171\/738409\/cs0430171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/2\/171\/738409\/cs0430171.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T11:32:05Z","timestamp":1638444725000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/43\/2\/171\/69504\/Initial-Increase-of-Plasma-Radioactive-Calcium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0430171","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1972,8,1]]}}}