{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:52:46Z","timestamp":1758124366426},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,8,1]]},"abstract":"<jats:p>1. Erythrocyte sodium concentration and fluxes were measured in patients with acid-base disturbances, hypokalaemia and hyponatraemia. Results were similar to those obtained with normal erythrocytes exposed to artificial in vitro alterations.<\/jats:p>\n               <jats:p>2. Erythrocyte sodium content and influx varied directly with extracellular bicarbonate which appeared to influence membrane permeability.<\/jats:p>\n               <jats:p>3. Hypokalaemia increased the erythrocyte sodium content by decreasing active transport initially. When a new high erythrocyte steady-state sodium concentration was reached, active transport returned to normal but efflux and influx were increased considerably by the appearance of a large component of exchange diffusion in the hypokalaemic environment.<\/jats:p>\n               <jats:p>4. Hyponatraemia induced a decrease in sodium influx secondary to the decreased transmembrane sodium concentration gradient. A decrease in erythrocyte sodium content then ensued.<\/jats:p>\n               <jats:p>5. The results are discussed in relation to the assessment of cell membrane function in disease states.<\/jats:p>","DOI":"10.1042\/cs0430251","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:05Z","timestamp":1438943165000},"page":"251-263","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Effects of Chronic Hypokalaemia, Hyponatraemia, and Acid-Base Alterations on Erythrocyte Sodium Transport"],"prefix":"10.1042","volume":"43","author":[{"given":"M. L.","family":"Levin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Texas, Southwestern Medical School, Dallas, Texas, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"F. C.","family":"Rector","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas, Southwestern Medical School, Dallas, Texas, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. W.","family":"Seldin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas, Southwestern Medical School, Dallas, Texas, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/2\/251\/738415\/cs0430251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/2\/251\/738415\/cs0430251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T11:38:14Z","timestamp":1638445094000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/43\/2\/251\/69524\/The-Effects-of-Chronic-Hypokalaemia-Hyponatraemia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1972,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0430251","relation":{},"ISSN":["0009-9287"],"issn-type":[{"type":"print","value":"0009-9287"}],"subject":[],"published":{"date-parts":[[1972,8,1]]}}}