{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:38:03Z","timestamp":1758814683721},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1972,9,1]]},"abstract":"<jats:p>1. Diurnal variations in urine calcium oxalate and calcium phosphate activity products were observed in normal men and patients with recurrent calcium oxalate or mixed oxalate\u2014phosphate renal stones.<\/jats:p>\n               <jats:p>2. Maximum and minimum calcium oxalate products were higher in the patients than in the controls, the difference being most marked in the patients with calcium oxalate stones.<\/jats:p>\n               <jats:p>3. Maximum and minimum calcium phosphate products expressed as octocalcium phosphate [(Ca8H2(PO4)6], brushite or hydroxyapatite, were significantly higher than normal in the patients with mixed stones but not in the patients with calcium oxalate stones.<\/jats:p>\n               <jats:p>4. The raised calcium oxalate products in the patients were due mainly to increased concentrations of Ca2+ ions; these, in turn, were due mainly to an increased rate of excretion of calcium. Raised calcium phosphate products were due mainly to hypercalciuria, combined with abnormally high urine pH values.<\/jats:p>\n               <jats:p>5. Patients with recurrent calcium stones appear to fall into two types: (1) patients with calcium oxalate stones associated with hypercalciuria, a normal or raised urine oxalate and a normal urine pH; (2) patients with mixed oxalate\u2014phosphate stones associated with hypercalciuria, a normal or raised urine oxalate and a raised urine pH.<\/jats:p>\n               <jats:p>6. The implications of these findings in regard to treatment are discussed.<\/jats:p>","DOI":"10.1042\/cs0430433","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:05Z","timestamp":1438943165000},"page":"433-441","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The Relation between the Concentration of Calcium Salts in the Urine and Renal Stone Composition in Patients with Calcium-Containing Renal Stones"],"prefix":"10.1042","volume":"43","author":[{"given":"R. W.","family":"Marshall","sequence":"first","affiliation":[{"name":"Medical Research Council Mineral Metabolism Unit, The General Infirmary, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cochran","sequence":"additional","affiliation":[{"name":"Medical Research Council Mineral Metabolism Unit, The General Infirmary, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. G.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Medical Research Council Mineral Metabolism Unit, The General Infirmary, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hodgkinson","sequence":"additional","affiliation":[{"name":"Medical Research Council Mineral Metabolism Unit, The General Infirmary, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. E. C.","family":"Nordin","sequence":"additional","affiliation":[{"name":"Medical Research Council Mineral Metabolism Unit, The General Infirmary, Leeds"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/3\/433\/814754\/cs0430433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/43\/3\/433\/814754\/cs0430433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T14:41:20Z","timestamp":1638456080000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/43\/3\/433\/69997\/The-Relation-between-the-Concentration-of-Calcium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0430433","relation":{},"ISSN":["0009-9287"],"issn-type":[{"value":"0009-9287","type":"print"}],"subject":[],"published":{"date-parts":[[1972,9,1]]}}}