{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:46:28Z","timestamp":1758815188777},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,3,1]]},"abstract":"<jats:p>1. The 24 h urinary excretion of noradrenaline and adrenaline is significantly lower in recumbent than ambulant normal subjects.<\/jats:p>\n               <jats:p>2. A diurnal variation exists in catecholamine excretion, the lowest values occurring during sleep.<\/jats:p>\n               <jats:p>3. Diurnal variation in sodium excretion parallels that in noradrenaline and adrenaline loss but the cycles can be separated by acute alterations in sleep\/awake pattern.<\/jats:p>\n               <jats:p>4. Diurnal variation is lost during exercise, after myocardial infarction and was absent pre-operatively in a patient with a phaeochromocytoma.<\/jats:p>\n               <jats:p>5. Acute alterations in renal blood flow, diuresis, natriuresis and urinary acidification do not alter catecholamine excretion significantly.<\/jats:p>\n               <jats:p>6. Urinary catecholamine excretion is related to physical activity and wakefulness; the normal diurnal variation is easily overriden by sustained sympatho-adrenal activity. Alterations in renal function in exercise or after myocardial infarction do not account for the observed increases in catecholamine excretion.<\/jats:p>","DOI":"10.1042\/cs0440253","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:08Z","timestamp":1438943168000},"page":"253-265","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Factors Influencing the Urinary Excretion of Free Catecholamines in Man"],"prefix":"10.1042","volume":"44","author":[{"given":"Mary M.","family":"Townshend","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics, The Royal Infirmary, Sheffield"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics, The Royal Infirmary, Sheffield"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/3\/253\/815217\/cs0440253.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/3\/253\/815217\/cs0440253.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:58:23Z","timestamp":1572051503000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/44\/3\/253\/69366\/Factors-Influencing-the-Urinary-Excretion-of-Free"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1973,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0440253","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1973,3,1]]}}}