{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:45:12Z","timestamp":1758278712394},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,4,1]]},"abstract":"<jats:p>1. Bone and calcium metabolism in protein-deprived 5-week-old male rats who exhibited no biochemical or histological features of rickets were compared with age-and weight-matched control animals.<\/jats:p>\n               <jats:p>2. Intestinal calcium absorption was significantly lower in protein-deprived rats. This was associated with a smaller exchangeable calcium pool and lower bone formation as measured by calcium accretion and proline incorporation into hydroxyproline. However, calcium resorption from bone barely changed in this group and a disproportionately high fraction of the calcium pool continued to be excreted.<\/jats:p>\n               <jats:p>3. As a consequence, retarded bone growth occurred in the protein-deprived rat, leading to bones which were shorter and lighter than those of age-matched control animals, the epiphyseal regions appearing to bear the brunt of the growth retardation. This was not accompanied by a change in quality of bone, as the percentage ash content of extirpated bone remained normal.<\/jats:p>\n               <jats:p>4. Though alternative hypotheses are possible, the data are consistent with a primary disturbance of intestinal, and possibly renal tubular, calcium transport, perhaps associated with impaired synthesis of calcium-binding protein. An independent depression of collagen synthesis is likely.<\/jats:p>","DOI":"10.1042\/cs0440305","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:08Z","timestamp":1438943168000},"page":"305-319","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Bone Metabolism and Composition in the Protein-Deprived Rat"],"prefix":"10.1042","volume":"44","author":[{"given":"D.","family":"Le Roith","sequence":"first","affiliation":[{"name":"Isotope Laboratory, Department of Medicine, Medical School, University of Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. L.","family":"Pimstone","sequence":"additional","affiliation":[{"name":"Isotope Laboratory, Department of Medicine, Medical School, University of Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/4\/305\/750844\/cs0440305.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/4\/305\/750844\/cs0440305.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T17:08:38Z","timestamp":1572196118000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/44\/4\/305\/70695\/Bone-Metabolism-and-Composition-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1973,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0440305","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1973,4,1]]}}}