{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:49:25Z","timestamp":1771645765848,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,4,1]]},"abstract":"<jats:p>1. Rats treated with disodium ethane-1-hydroxy-1,1-diphosphonate for 14 days developed rickets and impaired intestinal calcium transport, even when receiving large amounts of cholecalciferol (vitamin D3).<\/jats:p>\n               <jats:p>2. Vitamin d-deficient rats treated with the diphosphonate, and irrespective of the duration of such treatment, responded initially to a single intravenous dose of cholecalciferol with a normal production of 1,25-dihydroxycholecalciferol.<\/jats:p>\n               <jats:p>3. This normal response was followed within 2 days by an apparent inhibition of the renal biosynthesis of 1,25-dihydroxycholecalciferol. It is inferred that the impaired intestinal transport of calcium, in diphosphonate-treated rats receiving vitamin D, is due to a deficiency of this renal metabolite.<\/jats:p>\n               <jats:p>4. Inhibition of the synthesis of 1,25-dihydroxycholecalciferol could not be attributed to a direct action of the drug on the renal 1-hydroxylase, but appeared to be determined by the initial normal response to vitamin D.<\/jats:p>\n               <jats:p>5. The mechanisms possibly involved in producing this effect are discussed.<\/jats:p>","DOI":"10.1042\/cs0440335","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:26:08Z","timestamp":1438928768000},"page":"335-347","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Indirect Inhibition of the Biosynthesis of 1,25-Dihydroxycholecalciferol in Rats Treated with a Diphosphonate"],"prefix":"10.1042","volume":"44","author":[{"given":"L. F.","family":"Hill","sequence":"first","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Lumb","sequence":"additional","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B.","family":"Mawer","sequence":"additional","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Stanbury","sequence":"additional","affiliation":[{"name":"Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/4\/335\/750788\/cs0440335.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/4\/335\/750788\/cs0440335.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T05:14:42Z","timestamp":1572153282000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/44\/4\/335\/70687\/Indirect-Inhibition-of-the-Biosynthesis-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1973,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0440335","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1973,4,1]]}}}