{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T19:11:30Z","timestamp":1726513890485},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,5,1]]},"abstract":"<jats:p>1. The major collagen fraction of skin, which in vivo consists of tropocollagen molecules aggregated into extracellular fibres, has been extracted from forty-nine normal subjects and nineteen patients with inherited and acquired disorders of connective tissue.<\/jats:p>\n               <jats:p>2. In normal subjects the chemical stability of this fraction progressively increased up to the age of 60.<\/jats:p>\n               <jats:p>3. This fraction was less stable than normal in patients with homocystinuria, Werner's syndrome, myositis ossificans progressiva, pseudoxanthoma elasticum, juvenile osteoporosis and acromegaly.<\/jats:p>\n               <jats:p>4. In osteogenesis imperfecta (OI) the stability of this fraction was normal in those patients with markedly blue sclerae, although the amount which could be extracted from the skin was low: opposite results were found in those OI patients with sclerae of normal colour.<\/jats:p>\n               <jats:p>5. This study provides preliminary evidence of collagen abnormality in several heritable disorders of connective tissue.<\/jats:p>","DOI":"10.1042\/cs0440429","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:08Z","timestamp":1438943168000},"page":"429-438","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Polymeric Collagen of Skin in Normal Subjects and in Patients with Inherited Connective Tissue Disorders"],"prefix":"10.1042","volume":"44","author":[{"given":"M. J. O.","family":"Francis","sequence":"first","affiliation":[{"name":"Metabolic Unit, Nuffield Department of Orthopaedic Surgery, University of Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Metabolic Unit, Nuffield Department of Orthopaedic Surgery, University of Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Macmillan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Radclijfe Infirmary, Oxford"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/5\/429\/738461\/cs0440429.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/44\/5\/429\/738461\/cs0440429.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T16:54:01Z","timestamp":1571936041000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/44\/5\/429\/69390\/Polymeric-Collagen-of-Skin-in-Normal-Subjects-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1973,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0440429","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1973,5,1]]}}}