{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T21:46:49Z","timestamp":1649022409016},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1973,8,1]]},"abstract":"<jats:p>1. The hypotensive effect of spironolactone has been studied in twenty-four patients with various forms of hypertension.<\/jats:p>\n               <jats:p>2. In essential hypertension a greater fall of blood pressure was achieved in patients with renin activity hyporesponsive to postural change than in those in whom renin responded normally to posture.<\/jats:p>\n               <jats:p>3. A poor hypotensive response was observed in patients with renal or renal arterial disease and secondary aldosteronism.<\/jats:p>\n               <jats:p>4. The variable hypotensive response seen in patients with primary aldosteronism predicted the response to adrenal surgery.<\/jats:p>\n               <jats:p>5. Blood pressure was not lowered by spironolactone in one case of 17-hydroxylation deficiency or in one case of malignant ovarian arrhenoblastoma producing aldosterone.<\/jats:p>","DOI":"10.1042\/cs045219s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:26:23Z","timestamp":1438943183000},"page":"219s-224s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antihypertensive Effect of Spironolactone in Essential, Renal and Mineralocorticoid Hypertension"],"prefix":"10.1042","volume":"45","author":[{"given":"F.","family":"Mantero","sequence":"first","affiliation":[{"name":"1Istituto di Semeiotica Medica della Universita di Padova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Armanini","sequence":"additional","affiliation":[{"name":"2Istituto di Semeiotica Medica della Universita di Padova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Urbani","sequence":"additional","affiliation":[{"name":"3Istituto di Semeiotica Medica della Universita di Padova"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/45\/s1\/219s\/831215\/cs045219s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/45\/s1\/219s\/831215\/cs045219s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T12:49:35Z","timestamp":1572180575000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/45\/s1\/219s\/71755\/Antihypertensive-Effect-of-Spironolactone-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,8,1]]},"references-count":0,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[1973,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs045219s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1973,8,1]]}}}