{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:53:14Z","timestamp":1760100794671},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,1,1]]},"abstract":"<jats:p>1. An analysis was made of the relationship which exists between arterial [H+], Pco2 and [HCO3\u2212] in twenty-five patients with stable metabolic acidosis and alkalosis and in three normal subjects.<\/jats:p>\n               <jats:p>2. Contrary to previous reports, the relationship between Pco2 and [H+] was nonlinear and could best be described in terms of a rectangular hyperbola (Pco2 = 962\/([H+]-12).<\/jats:p>\n               <jats:p>3. The relationship between Pco2 and [HCO3\u2212] was curvilinear and best described by the quadratic function 23.8 (Pco2)2\u221212Pco2[HCO3\u2212] \u2212962 [HCO3\u2212] = 0.<\/jats:p>\n               <jats:p>4. The small acute changes in [H+],\u2212[HCO3\u2212] and Pco2 produced by infusion of the weak organic acid 5,5\u2212dimethyl 2,4\u2212oxazolidinedione (DMO) could be predicted from the curvilinear regression.<\/jats:p>","DOI":"10.1042\/cs0460113","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:27:22Z","timestamp":1438943242000},"page":"113-123","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Relationship between Arterial Pco2 and Hydrogen Ion Concentration in Chronic Metabolic Acidosis and Alkalosis"],"prefix":"10.1042","volume":"46","author":[{"given":"J. M.","family":"Bone","sequence":"first","affiliation":[{"name":"Medical Renal Unit, Department of Medicine of the University of Edinburgh, Royal Infirmary, Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cowie","sequence":"additional","affiliation":[{"name":"Medical Renal Unit, Department of Medicine of the University of Edinburgh, Royal Infirmary, Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne T.","family":"Lambie","sequence":"additional","affiliation":[{"name":"Medical Renal Unit, Department of Medicine of the University of Edinburgh, Royal Infirmary, Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Robson","sequence":"additional","affiliation":[{"name":"Medical Renal Unit, Department of Medicine of the University of Edinburgh, Royal Infirmary, Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/46\/1\/113\/746675\/cs0460113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/46\/1\/113\/746675\/cs0460113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T19:24:10Z","timestamp":1572204250000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/46\/1\/113\/70716\/The-Relationship-between-Arterial-Pco2-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0460113","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1974,1,1]]}}}