{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T11:16:34Z","timestamp":1649070994366},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,7,1]]},"abstract":"<jats:p>1. Serial changes in plasma renin activity and plasma angiotensin levels were followed in rats during acute renal failure induced by mercuric chloride or glycerol.<\/jats:p>\n               <jats:p>2. During mercuric chloride-induced acute renal failure there were transitory large increases in plasma renin and angiotensin. In contrast, rats with acute renal failure produced by glycerol had a reduction in plasma renin and angiotensin levels at 1 h, after which the levels returned to control values.<\/jats:p>\n               <jats:p>3. There was no correlation between the systemic changes in plasma renin and angiotensin and the mortality from or severity of the renal failure.<\/jats:p>\n               <jats:p>4. Passive or active immunization of rats to angiotensin afforded no protection against renal failure associated with either glycerol or mercuric chloride.<\/jats:p>\n               <jats:p>5. It is concluded that the renin-angiotensin system plays no direct systemic vasoconstrictor role in the production of acute renal failure in these experimental models in rats.<\/jats:p>","DOI":"10.1042\/cs0470079","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:28:01Z","timestamp":1438928881000},"page":"79-88","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Renin-Angiotensin System in Acute Renal Failure in Rats"],"prefix":"10.1042","volume":"47","author":[{"given":"P. G.","family":"Matthews","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Melbourne, Austin and Repatriation Hospitals, Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. O.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Melbourne, Austin and Repatriation Hospitals, Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. I.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Melbourne, Austin and Repatriation Hospitals, Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/47\/1\/79\/753896\/cs0470079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/47\/1\/79\/753896\/cs0470079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T01:14:35Z","timestamp":1572052475000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/47\/1\/79\/69831\/The-ReninAngiotensin-System-in-Acute-Renal-Failure"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0470079","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1974,7,1]]}}}