{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T15:12:53Z","timestamp":1747753973298},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,1,1]]},"abstract":"<jats:p>1. Angiotensin is produced by the intrinsic iso-renin-angiotensin system.<\/jats:p>\n               <jats:p>2. Angiotensin is secreted into the cerebrospinal fluid of nephrectomized rats.<\/jats:p>\n               <jats:p>3. Angiotensin in cerebrospinal fluid elevates systemic blood pressure.<\/jats:p>\n               <jats:p>4. Rats with hereditary diabetes insipidus are virtually non-responsive to intraventricular angiotensin.<\/jats:p>\n               <jats:p>5. Angiotensin II is elevated in the cerebrospinal fluid of spontaneously hypertensive rats.<\/jats:p>\n               <jats:p>6. An intraventricular perfusion of the angiotensin II receptor-blocking agent P 113 decreases blood pressure in spontaneously hypertensive rats.<\/jats:p>","DOI":"10.1042\/cs048265s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:28:35Z","timestamp":1438928915000},"page":"265s-268s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Intrinsic Brain Iso-Renin-Angiotensin System in the Rat: Its Possible Role in Central Mechanisms of Blood Pressure Regulation"],"prefix":"10.1042","volume":"48","author":[{"given":"D.","family":"Ganten","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Schelling","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/48\/s2\/265s\/815814\/cs048265s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/48\/s2\/265s\/815814\/cs048265s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T05:04:38Z","timestamp":1572066278000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/48\/s2\/265s\/71848\/The-Intrinsic-Brain-IsoReninAngiotensin-System-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1,1]]},"references-count":0,"journal-issue":{"issue":"s2","published-print":{"date-parts":[[1974,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs048265s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1974,1,1]]}}}