{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T02:30:58Z","timestamp":1648866658244},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1975,8,1]]},"abstract":"<jats:p>1. The bivalent cation-binding agent, cellulose phosphate, together with a low calcium diet was given for 6 days to nine patients with primary hyperparathyroidism subsequently verified at surgery.<\/jats:p>\n               <jats:p>2. Urinary calcium fell promptly by 8\u00b74 mmol\/24 h, and by 70%, and reached amounts below 4\u00b70 mmol\/24 h in five of the nine patients. The magnitude of fall may have been related to increased synthesis of vitamin D by the skin in a sub-tropical environment. Plasma magnesium fell steadily and urinary magnesium fell by 80%.<\/jats:p>\n               <jats:p>3. The plasma calcium showed two types of response. In five patients there was no significant change because a reduction in calcium load was offset by a further increase in the already high tubular reabsorption of calcium. In the remaining four patients, the tubular reabsorption of calcium was at a higher level initially and failed to increase further on the experimental regime, with a corresponding fall in plasma calcium.<\/jats:p>\n               <jats:p>4. The hypercalcaemia of primary hyperparathyroidism can be explained by increased gastrointestinal absorption and increased renal tubular reabsorption of calcium; net bone resorption makes only a small contribution but an additional factor dependent on the blood-bone equilibrium is not ruled out.<\/jats:p>\n               <jats:p>5. Comparison with other published data suggests that the fall in urinary calcium in response to a calcium-depleting regimen is prevented by concurrent depletion of inorganic phosphate and may be enhanced by concurrent depletion of magnesium.<\/jats:p>\n               <jats:p>6. Persistence of hypercalcaemia combined with an increase in tubular reabsorption of calcium in response to cellulose phosphate may be of diagnostic value in suspected primary hyperparathyroidism.<\/jats:p>\n               <jats:p>7. Cellulose phosphate may be of value in stone prevention in patients with primary hyperparathyroidism who are unsuitable for surgical treatment.<\/jats:p>","DOI":"10.1042\/cs0490091","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:29:47Z","timestamp":1438943387000},"page":"91-98","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Cellulose Phosphate and Dietary Calcium Restriction in Primary Hyperparathyroidism"],"prefix":"10.1042","volume":"49","author":[{"given":"A. M.","family":"Parfitt","sequence":"first","affiliation":[{"name":"University of Queensland, Department of Medicine, Royal Brisbane Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/49\/2\/91\/815603\/cs0490091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/49\/2\/91\/815603\/cs0490091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T23:53:39Z","timestamp":1572220419000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/49\/2\/91\/70451\/Effect-of-Cellulose-Phosphate-and-Dietary-Calcium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1975,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0490091","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1975,8,1]]}}}