{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:55:08Z","timestamp":1715536508471},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1975,10,1]]},"abstract":"<jats:p>1. Intravenous frusemide produced in normal subjects a prompt rise of plasma renin concentration which correlated with urinary sodium.<\/jats:p>\n               <jats:p>2. The renin response to frusemide was suppressed in patients with primary hyperaldosteronism.<\/jats:p>\n               <jats:p>3. In patients with low-renin hypertension and normal renin essential hypertension, the renin response to frusemide was similarly suppressed.<\/jats:p>\n               <jats:p>4. Suppression of the renin response to frusemide is therefore a feature of hypertension not confined to patients with primary hyperaldosteronism and low-renin hypertension.<\/jats:p>\n               <jats:p>5. Thus low-renin hypertension does not appear to constitute a distinct diagnostic entity.<\/jats:p>\n               <jats:p>6. It is suggested that suppression of the renin response is part of a long-term renal adaptation to high blood pressure.<\/jats:p>","DOI":"10.1042\/cs0490353","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:29:47Z","timestamp":1438943387000},"page":"353-358","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Intravenous Frusemide on Plasma Renin Concentration: Suppression of Response in Hypertension"],"prefix":"10.1042","volume":"49","author":[{"given":"P. L.","family":"Padfield","sequence":"first","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E. M.","family":"Allison","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Infirmary, Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Brown","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. F.","family":"Lever","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Luke","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Infirmary, Glasgow Scotland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Robertson","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I. S.","family":"Robertson","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tree","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Unit, Western Infirmary, Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/49\/4\/353\/738940\/cs0490353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/49\/4\/353\/738940\/cs0490353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T07:21:42Z","timestamp":1572074502000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/49\/4\/353\/70298\/Effect-of-Intravenous-Frusemide-on-Plasma-Renin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1975,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0490353","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1975,10,1]]}}}