{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:12:53Z","timestamp":1762161173267},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,12,1]]},"abstract":"<jats:p>1. Kidney weight and content of protein, RNA and DNA were measured in rats with streptozotocin diabetes of varying duration.<\/jats:p>\n               <jats:p>2. Diabetic rats had larger kidneys than control rats: after 3 days of diabetes the weight increase was 15% and after 42 days of diabetes it was 90%. The protein content rose in parallel to the weight.<\/jats:p>\n               <jats:p>3. RNA content was already increased after 36 h of glycosuria, whereas DNA content was unchanged for the first 3 days of diabetes, and increased thereafter. The protein\/DNA ratio increased rapidly during the first 3 days but remained constant thereafter.<\/jats:p>\n               <jats:p>4. Insulin treatment decreased the renal weight gain by about 67% during the first 8 days of diabetes, but did not prevent the increase in DNA. When insulin was started after 25 days of diabetes there was only a slight regression of kidney growth.<\/jats:p>","DOI":"10.1042\/cs0510551","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:31:32Z","timestamp":1438943492000},"page":"551-555","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Renal Hypertrophy in Streptozotocin-Diabetic Rats"],"prefix":"10.1042","volume":"51","author":[{"given":"K.","family":"Seyer-Hansen","sequence":"first","affiliation":[{"name":"Second University Clinic of Internal Medicine, Kommunehospitalet, Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/6\/551\/754200\/cs0510551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/6\/551\/754200\/cs0510551.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T21:15:20Z","timestamp":1571951720000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/6\/551\/70581\/Renal-Hypertrophy-in-StreptozotocinDiabetic-Rats"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1976,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0510551","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1976,12,1]]}}}