{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T15:21:57Z","timestamp":1649172117336},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. Indomethacin inhibits prostaglandin synthesis and interferes with renin release; these effects were studied in rabbit renovascular hypertension.<\/jats:p>\n               <jats:p>2. Ten intravenous inject ons (3 mg day\u20141 kg\u20141 after two initial doses of 9 mg\/kg) of indomethacin were given daily to ten normal rabbits, ten rabbits with two-kidney Goldblatt hypertension (2KH), and ten rabbits with one-kidney Goldblatt hypertension (1KH). Twelve appropriate control rabbits received diluent phosphate buffer without indomethacin. Plasma renin activity and plasma prostaglandin E2 were measured by radioimmunoassay.<\/jats:p>\n               <jats:p>3. In the normal group, indomethacin significantly decreased plasma prostaglandin E2 (1\u00b715 to 0\u00b72 ng\/ml, sem 0\u00b72; P &lt; 0\u00b701) and plasma renin activity (20 to 3 ng h\u20141 ml\u20141, sem 1, P &lt; 0\u00b701). Plasma creatinine increased slightly but the mean blood pressure was not significantly changed by indomethacin.<\/jats:p>\n               <jats:p>4. Six of ten rabbits with 2KH showed results similar to those in the normal rabbits. In four of ten rabbits in which development of 2KH was accompanied by increments in plasma renin activity (18 to 31\u00b75 ng h\u20141 ml\u20141, sem 3 and 4 respectively; P &lt; 0\u00b701) and plasma prostaglandin E2 (1\u00b72 to 3\u00b74 ng\/ml, sem 0\u00b72 and 0\u00b74 respectively; P &lt; 0\u00b705), treatment with indomethacin produced renal failure (plasma creatinine increasing to 7\u00b76 mg\/100 ml), oliguria, malignant hypertension (mean blood pressure, 168 mmHg, sem 7\u00b77) and death within 5 days.<\/jats:p>\n               <jats:p>5. In 1KH, indomethacin decreased plasma renin activity and plasma prostaglandin E2, but caused increased mean blood pressure (102 to 121 mmHg, sem 4 and 6 respectively; P &lt; 0\u00b701) and decreased renal function (plasma creatinine 0\u00b79 \u00b1 0\u00b704 to 3\u00b75 \u00b1 1 mg\/100 ml, sem 0\u00b704 and 1 respectively; P &lt; 0\u00b701).<\/jats:p>\n               <jats:p>6. Aggravation of hypertension was conditioned by pre-existing levels of renal function and, to a lesser extent, by plasma renin activities.<\/jats:p>\n               <jats:p>7. These results suggest that prostaglandins exert a protective effect on renal function in renovascular hypertension.<\/jats:p>","DOI":"10.1042\/cs051249s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:31:32Z","timestamp":1438929092000},"page":"249s-251s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Indomethacin in Rabbit Renovascular Hypertension"],"prefix":"10.1042","volume":"51","author":[{"given":"C. G.","family":"Strong","sequence":"first","affiliation":[{"name":"Mayo Clinic and Mayo Foundation, Rochester, Minnesota, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Romero","sequence":"additional","affiliation":[{"name":"Mayo Clinic and Mayo Foundation, Rochester, Minnesota, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/249s\/817188\/cs051249s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/249s\/817188\/cs051249s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T05:08:50Z","timestamp":1572066530000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/249s\/101604\/Effects-of-Indomethacin-in-Rabbit-Renovascular"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051249s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}