{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T13:32:52Z","timestamp":1648906372214},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. Using a newly developed and validated radio-assay method, we have measured plasma 11-deoxycorticosterone concentrations in a wide spectrum of human hypertensive states.<\/jats:p>\n               <jats:p>2. Patients with essential and renovascular hypertension have normal plasma concentrations of 11-deoxycorticosterone.<\/jats:p>\n               <jats:p>3. Elevated concentrations are seen in some patients with primary aldosteronism, Cushing's syndrome, low-renin hypertension, and in adult hypertensive subjects with elevated urinary 17-ketosteroid excretion.<\/jats:p>\n               <jats:p>4. An aetiological role for deoxycorticosterone in certain forms of human hypertension appears likely.<\/jats:p>","DOI":"10.1042\/cs051311s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:31:32Z","timestamp":1438929092000},"page":"311s-314s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of 11-Deoxycorticosterone in Human Hypertension"],"prefix":"10.1042","volume":"51","author":[{"given":"S. Y.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Noth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Mulrow","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/311s\/817162\/cs051311s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/311s\/817162\/cs051311s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T13:38:20Z","timestamp":1571924300000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/311s\/101582\/The-Role-of-11Deoxycorticosterone-in-Human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051311s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}