{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T05:35:52Z","timestamp":1648704952371},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. Oral and intravenous administration of metoprolol to adult spontaneously hypertensive rats (SHR) with established hypertension lowered arterial blood pressure within 4 days of treatment.<\/jats:p>\n               <jats:p>2. Steady-state plasma concentrations of metoprolol were similar to those of patients during antihypertensive treatment with this drug.<\/jats:p>\n               <jats:p>3. The neuroeffector function of portal veins of SHR treated orally for 14 days or intravenously for 4 days was not impaired when studied in vitro. This is in contrast to previous findings after long-term treatment.<\/jats:p>\n               <jats:p>4. It is concluded that the anti-hypertensive effect of metoprolol in SHR in many respects resembles that observed in patients. It is suggested that impairment of vasomotor nerve control may contribute to the anti-hypertensive effect of \u03b2-adrenoreceptor antagonists.<\/jats:p>","DOI":"10.1042\/cs051443s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:31:32Z","timestamp":1438929092000},"page":"443s-445s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Hypertensive Effect of Metoprolol in Spontaneously Hypertensive Rats"],"prefix":"10.1042","volume":"51","author":[{"given":"B.","family":"Ljung","sequence":"first","affiliation":[{"name":"Research Laboratories, AB H\u00e4ssle, M\u00f6lndal, and Department of Physiology, University of G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"\u00c5blad","sequence":"additional","affiliation":[{"name":"Research Laboratories, AB H\u00e4ssle, M\u00f6lndal, and Department of Physiology, University of G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Drews","sequence":"additional","affiliation":[{"name":"Research Laboratories, AB H\u00e4ssle, M\u00f6lndal, and Department of Physiology, University of G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Fellenius","sequence":"additional","affiliation":[{"name":"Research Laboratories, AB H\u00e4ssle, M\u00f6lndal, and Department of Physiology, University of G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kjellstedt","sequence":"additional","affiliation":[{"name":"Research Laboratories, AB H\u00e4ssle, M\u00f6lndal, and Department of Physiology, University of G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wallborg","sequence":"additional","affiliation":[{"name":"Research Laboratories, AB H\u00e4ssle, M\u00f6lndal, and Department of Physiology, University of G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/443s\/816998\/cs051443s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/443s\/816998\/cs051443s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T17:05:55Z","timestamp":1571936755000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/443s\/101546\/AntiHypertensive-Effect-of-Metoprolol-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051443s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}