{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T01:24:10Z","timestamp":1648862650765},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. Acebutolol, a \u03b21-receptor blocker, has, at a daily dose of 800 mg, a mild but significant anti-hypertensive effect in moderate sustained essential hypertension with normal or low plasma renin activity.<\/jats:p>\n               <jats:p>2. Prediction of its anti-hypertensive effect is better based on the evaluation of the sympathetic nervous system responsiveness to head-up tilt than on the evaluation of plasma renin activity or dopamine-\u03b2-hydroxylase.<\/jats:p>\n               <jats:p>3. The anti-hypertensive effect of acebutolol is better explained on the basis of inhibition of the sympathetic nervous system activity than on the basis of suppression of plasma renin activity.<\/jats:p>\n               <jats:p>4. A positive correlation between plasma renin activity and dopamine-\u03b2-hydroxylase in patients on diuretics suggests the common dependence of these two variables on sympathetic overactivity.<\/jats:p>","DOI":"10.1042\/cs051477s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:31:32Z","timestamp":1438943492000},"page":"477s-480s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Hypertensive Effect of Acebutolol: Its Relation to Sympathetic Nervous System Responsiveness and to Plasma Renin and Dopamine-\u03b2-Hydroxylase Activities"],"prefix":"10.1042","volume":"51","author":[{"given":"A.","family":"Fournier","sequence":"first","affiliation":[{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Hardin","sequence":"additional","affiliation":[{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Alexandre","sequence":"additional","affiliation":[{"name":"Laboratoire de Pharmacologic, H\u00f4pital Broussais, Paris, France"},{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lombaert","sequence":"additional","affiliation":[{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ronco","sequence":"additional","affiliation":[{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Bezoc","sequence":"additional","affiliation":[{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Desmet","sequence":"additional","affiliation":[{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Quichaud","sequence":"additional","affiliation":[{"name":"Chu d'Amiens, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/477s\/817284\/cs051477s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/477s\/817284\/cs051477s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T04:03:16Z","timestamp":1572062596000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/477s\/101628\/AntiHypertensive-Effect-of-Acebutolol-Its-Relation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051477s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}