{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T12:26:48Z","timestamp":1648902408087},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. Immediate and long-term blood pressure-lowering activity of five \u03b2-adrenoreceptor antagonists with different ancillary pharmacological properties were compared in a randomized double-blind placebo controlled factorial trial in twenty-five previously untreated patients with stable uncomplicated essential hypertension.<\/jats:p>\n               <jats:p>2. In doses which produced similar reductions in exercise tachycardia, all drugs exerted similar antihypertensive activity, which was greater on systolic than diastolic pressure and greatest during exercise.<\/jats:p>\n               <jats:p>3. These effects were maximum within an hour and lasted for over 8 h after a single oral dose.<\/jats:p>\n               <jats:p>4. Blood pressure-lowering activity, particularly the reduction in exercise systolic pressure, was significantly related to the logarithm of the dose of each drug.<\/jats:p>\n               <jats:p>5. Anti-hypertensive activity was maximally enhanced after 4 weeks of sustained treatment at any given dose. There was no short-term habituation to treatment and substitution with placebo resulted in a return of the blood pressure to pretreatment values within 4 weeks without subsequent overshoot.<\/jats:p>\n               <jats:p>6. The blood pressure-lowering activity of these drugs was predominantly related to their common property of competitive antagonism of cardiac \u03b2-adrenoreceptors; their ancillary pharmacological properties, with the exception of intrinsic vasodilator activity, played little part in this response.<\/jats:p>","DOI":"10.1042\/cs051541s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:31:32Z","timestamp":1438929092000},"page":"541s-544s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Anti-Hypertensive Effectiveness of \u03b2-Adrenoreceptor Antagonists with Different Pharmacological Properties: Dose\u2014Response Studies during Acute and Chronic Administration"],"prefix":"10.1042","volume":"51","author":[{"given":"S. H.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Medical Cardiology and University Departments of Medicine and Cardiovascular Studies, The General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Medical Cardiology and University Departments of Medicine and Cardiovascular Studies, The General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Singleton","sequence":"additional","affiliation":[{"name":"Department of Medical Cardiology and University Departments of Medicine and Cardiovascular Studies, The General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Thadani","sequence":"additional","affiliation":[{"name":"Department of Medical Cardiology and University Departments of Medicine and Cardiovascular Studies, The General Infirmary, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/541s\/817276\/cs051541s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/541s\/817276\/cs051541s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:27:44Z","timestamp":1572002864000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/541s\/101640\/Comparative-AntiHypertensive-Effectiveness-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051541s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}