{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:46:16Z","timestamp":1759333576262},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. One hundred patients with severe essential hypertension have been treated with minoxidil for a mean period of 8\u00b74 months in a study involving eleven European centres. Seventy-two males and twenty-eight females were included in the group; the mean age was 55 years and the initial supine systolic and diastolic pressures averaged 212 (range 150\u2013270) and 125 (range 90\u2013150) mmHg respectively.<\/jats:p>\n               <jats:p>2. Reduction of supine diastolic pressure to less than 100 mmHg occurred in 94% of patients within 4 weeks. After the average follow-up period of 8\u00b74 months the mean pressures were 151\/91 mmHg. Concomitant therapy with \u03b2-receptor-blocking agents and diuretics resulted in satisfactory control of heart rate and weight gain.<\/jats:p>\n               <jats:p>3. Side effects included increased hair growth, nausea, fatigue, rash and darkening of the skin. ECG showed mainly T-wave changes and echocardiographic examination indicated improved ventricular emptying.<\/jats:p>","DOI":"10.1042\/cs051579s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:31:32Z","timestamp":1438943492000},"page":"579s-581s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The use of Minoxidil in the Treatment of Severe Essential Hypertension: A Report on 100 Patients"],"prefix":"10.1042","volume":"51","author":[{"given":"R. G.","family":"Jacomb","sequence":"first","affiliation":[{"name":"Upjohn Ltd, Crawley, West Sussex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Brunnberg","sequence":"additional","affiliation":[{"name":"Upjohn GmbH, Heppenheim, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/579s\/817018\/cs051579s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/579s\/817018\/cs051579s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T09:05:02Z","timestamp":1572080702000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/579s\/101539\/The-use-of-Minoxidil-in-the-Treatment-of-Severe"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051579s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}