{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T20:55:25Z","timestamp":1648932925490},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. Twenty patients with severe or moderate hypertension were treated with minoxidil for 284 patient-months.<\/jats:p>\n               <jats:p>2. The blood pressure was controlled in all patients, including those refractory to maximal doses of conventional anti-hypertensive agents.<\/jats:p>\n               <jats:p>3. In patients with moderate hypertension control with minoxidil was achieved earlier and more easily than with hydrallazine.<\/jats:p>\n               <jats:p>4. Three patients developed secondary resistance and required addition of guanethidine or increased doses of diuretics.<\/jats:p>\n               <jats:p>5. Fluid retention and hypertrichosis were the main side effects with minoxidil.<\/jats:p>","DOI":"10.1042\/cs051583s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:31:32Z","timestamp":1438943492000},"page":"583s-585s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of Severe and Moderate Hypertension with Minoxidil: Experience in Twenty-Eight Patients"],"prefix":"10.1042","volume":"51","author":[{"given":"G.","family":"Dunea","sequence":"first","affiliation":[{"name":"Division of Nephrology-Hypertension, Cook County Hospital, the Hektoen Institute for Medical Research and University of Health Sciences, Chicago Medical School, Chicago, Illinois, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Mamdani","sequence":"additional","affiliation":[{"name":"Division of Nephrology-Hypertension, Cook County Hospital, the Hektoen Institute for Medical Research and University of Health Sciences, Chicago Medical School, Chicago, Illinois, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. D.","family":"Mahurkar","sequence":"additional","affiliation":[{"name":"Division of Nephrology-Hypertension, Cook County Hospital, the Hektoen Institute for Medical Research and University of Health Sciences, Chicago Medical School, Chicago, Illinois, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/583s\/817050\/cs051583s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/583s\/817050\/cs051583s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T16:42:43Z","timestamp":1571935363000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/583s\/101547\/Treatment-of-Severe-and-Moderate-Hypertension-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051583s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}