{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T00:39:18Z","timestamp":1649032758328},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. A cross-over study was done in twenty patients with hypertension to compare the effects of chlorothiazide (0\u00b75 g twice daily) and metolazone (5 mg daily) in combination with other anti-hypertensive agents.<\/jats:p>\n               <jats:p>2. Compared with absence of diuretic therapy, chlorothiazide and metolazone both produced significantly lower blood pressures.<\/jats:p>\n               <jats:p>3. Blood pressures on metolazone tended to be lower than on chlorothiazide but this difference was not statistically significant.<\/jats:p>\n               <jats:p>4. Both diuretics significantly lowered serum potassium concentrations and total body potassium to a similar degree, but the serum potassium did not fall below the normal range in any patient and no potassium supplements were needed. No electrocardiographic changes suggestive of hypokalaemia were noted.<\/jats:p>\n               <jats:p>5. Small but significant increases in serum bicarbonate, calcium, urea and uric acid were observed with both diuretics.<\/jats:p>\n               <jats:p>6. Patient acceptance was excellent and no adverse effects were encountered.<\/jats:p>","DOI":"10.1042\/cs051627s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:31:32Z","timestamp":1438943492000},"page":"627s-629s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comparison of the Effects of Chlorothiazide and of Metolazone in the Treatment of Hypertension"],"prefix":"10.1042","volume":"51","author":[{"given":"A. S. P.","family":"Hua","sequence":"first","affiliation":[{"name":"Department of Nephrology and University Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Kincaid-Smith","sequence":"additional","affiliation":[{"name":"Department of Nephrology and University Department of Medicine, The Royal Melbourne Hospital, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/627s\/817468\/cs051627s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/627s\/817468\/cs051627s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T02:24:36Z","timestamp":1572056676000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/627s\/101664\/A-Comparison-of-the-Effects-of-Chlorothiazide-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051627s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}