{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T06:52:38Z","timestamp":1648968758493},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,1,1]]},"abstract":"<jats:p>1. The National Blood Pressure Study (NBPS) is a single blind trial designed to test the efficacy of active drug treatment in reducing complications from mild hypertension (mean diastolic pressure = 95\u2013109 mmHg).<\/jats:p>\n               <jats:p>2. Between 1973 and 1975, four centres screened about 104 000 subjects aged 30\u201369 years, yielding an estimated prevalence of hypertension (\u226595 mmHg diastolic) of 16% and of moderate-to-severe hypertension (\u2265110 mmHg diastolic) of 1\u00b73%.<\/jats:p>\n               <jats:p>3. Some 4000 subjects selected for untreated uncomplicated mild hypertension were randomized to either active treatment (chlorothiazide + \u03b1-methyldopa and\/or a \u03b2-adrenoreceptor antagonist as required) or to matching placebos.<\/jats:p>\n               <jats:p>4. At 1 year mean pressures had fallen significantly below entry pressures in both groups but in the active group the fall was greater by a margin of 14\u00b74\u00b11\u00b73 (sem) mmHg systolic and 71 \u00b10\u00b77 mmHg diastolic. At 1 year 5% of subjects in the placebo group had been placed on active treatment on the ethical grounds that pressure had exceeded the mild hypertension limit.<\/jats:p>\n               <jats:p>5. Trial end-points (death, morbidity from stroke, hypertensive heart and renal disease, and ischaemic heart disease) number 106 (nine deaths) thus far, of which ischaemic heart disease accounts for 71% and stroke 19%.<\/jats:p>\n               <jats:p>6. The duration of trial may need to be extended beyond the original estimate of 5 years.<\/jats:p>","DOI":"10.1042\/cs051645s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:31:32Z","timestamp":1438929092000},"page":"645s-647s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Report on Progress in the Australian National Blood Pressure Study (NBPS)"],"prefix":"10.1042","volume":"51","author":[{"given":"J. D.","family":"Abernethy","sequence":"first","affiliation":[{"name":"National Heart Foundation of Australia, Canberra, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Baker","sequence":"additional","affiliation":[{"name":"National Heart Foundation of Australia, Canberra, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. U.","family":"Bullen","sequence":"additional","affiliation":[{"name":"National Heart Foundation of Australia, Canberra, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Lamb","sequence":"additional","affiliation":[{"name":"National Heart Foundation of Australia, Canberra, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Stewart","sequence":"additional","affiliation":[{"name":"National Heart Foundation of Australia, Canberra, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/645s\/817022\/cs051645s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/51\/s3\/645s\/817022\/cs051645s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T23:59:11Z","timestamp":1571961551000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/51\/s3\/645s\/101535\/Report-on-Progress-in-the-Australian-National"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,1,1]]},"references-count":0,"journal-issue":{"issue":"s3","published-print":{"date-parts":[[1976,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs051645s","relation":{},"ISSN":["0144-4107"],"issn-type":[{"value":"0144-4107","type":"print"}],"subject":[],"published":{"date-parts":[[1976,1,1]]}}}