{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T22:59:08Z","timestamp":1726268348936},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,2,1]]},"abstract":"<jats:p>1. In four patients with nephrotic syndrome indomethacin not only reduced proteinuria but also inhibited the natriuretic effect of high doses of frusemide.<\/jats:p>\n               <jats:p>2. The inhibition of natriuresis by indomethacin could not be antagonized by albumin infusions.<\/jats:p>\n               <jats:p>3. Only the combined use of spironolactone and frusemide induced a natriuresis during indomethacin treatment. Spironolactone alone was ineffective.<\/jats:p>\n               <jats:p>4. It is suggested that inhibition of prostaglandin synthesis by indomethacin, in the presence of a stimulated renin-angiotensin system and hyperaldosteronism, may cause this strong tendency to sodium retention.<\/jats:p>","DOI":"10.1042\/cs0520149","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:32:03Z","timestamp":1438929123000},"page":"149-151","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inhibition of Frusemide-Induced Natriuresis by Indomethacin in Patients with the Nephrotic Syndrome"],"prefix":"10.1042","volume":"52","author":[{"given":"R. G. W. L.","family":"Tiggeler","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A. P.","family":"Koene","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. G. A. B.","family":"Wijdeveld","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/2\/149\/817670\/cs0520149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/2\/149\/817670\/cs0520149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T05:46:47Z","timestamp":1572155207000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/52\/2\/149\/73180\/Inhibition-of-FrusemideInduced-Natriuresis-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0520149","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,2,1]]}}}