{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T19:18:30Z","timestamp":1715541510527},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,3,1]]},"abstract":"<jats:p>1. Blood pressure and plasma renin activity were studied after bilateral nephrectomy in groups of rats with hypertension caused by unilateral renal ischaemia with the opposite kidney left intact.<\/jats:p>\n               <jats:p>2. Although blood pressure showed only a small fall in the first hour after bilateral nephrectomy, plasma renin activity fell rapidly with a half-life of 10 min.<\/jats:p>\n               <jats:p>3. Infusion of converting enzyme inhibitor (SQ20881) produced a 26\u00b71% fall in blood pressure 1 h after nephrectomy, 24\u00b70% at 2 h and 4\u00b76% at 6 h.<\/jats:p>\n               <jats:p>4. An angiotensin antagonist (Sar1-Ala8-angiotensin II) was infused into hypertensive rats 1 h after nephrectomy; this blocked the vasodepressor action of the converting enzyme inhibitor, indicating that the fall in blood pressure produced by the inhibitor was due to its action upon the renin-angiotensin system.<\/jats:p>\n               <jats:p>5. The renin\u2014angiotensin system maintains blood pressure in this model even after plasma renin has fallen to insignificant levels. This supports the view that vascular renin activity has a longer half-life than circulating renin and is important in the control of blood pressure.<\/jats:p>","DOI":"10.1042\/cs0520299","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T06:32:03Z","timestamp":1438929123000},"page":"299-304","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Blood Pressure Response of Nephrectomized Hypertensive Rats to Converting Enzyme Inhibition: Evidence for Persistent Vascular Renin Activity"],"prefix":"10.1042","volume":"52","author":[{"given":"H.","family":"Thurston","sequence":"first","affiliation":[{"name":"Department of Medicine, The General Hospital, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Swales","sequence":"additional","affiliation":[{"name":"Department of Medicine, The General Hospital, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/3\/299\/818191\/cs0520299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/3\/299\/818191\/cs0520299.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T04:04:31Z","timestamp":1572149071000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/52\/3\/299\/70321\/Blood-Pressure-Response-of-Nephrectomized"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0520299","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,3,1]]}}}