{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T20:44:09Z","timestamp":1648759449884},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,4,1]]},"abstract":"<jats:p>1. In the early phase of hypertension produced by renal artery constriction with the opposite kidney intact, infusion of the angiotensin antagonist Sar1-Ala8-angiotensin II or bilateral nephrectomy lowered blood pressure. However, the extent of the fall was variable and some animals remained hypertensive after each procedure.<\/jats:p>\n               <jats:p>2. To assess whether sodium retention was the additional factor which maintained blood pressure when the renin\u2014angiotensin system was suppressed, rats were maintained on a low-salt diet before and during the development of hypertension. The blood pressure-lowering effect of bilateral nephrectomy or antagonist infusion was not enhanced.<\/jats:p>\n               <jats:p>3. Infusion of antagonist or converting-enzyme inhibitor 6 h after bilateral nephrectomy had only a minor blood pressure-lowering action, indicating that, at this late stage after nephrectomy, the renin\u2014angiotensin system makes only a very small contribution to blood pressure maintenance.<\/jats:p>","DOI":"10.1042\/cs0520371","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:32:03Z","timestamp":1438943523000},"page":"371-375","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sodium Restriction and Inhibition of the Renin\u2014Angiotensin System in Renovascular Hypertension in the Rat"],"prefix":"10.1042","volume":"52","author":[{"given":"J. D.","family":"Swales","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/4\/371\/818229\/cs0520371.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/4\/371\/818229\/cs0520371.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T13:54:21Z","timestamp":1572011661000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/52\/4\/371\/70791\/Sodium-Restriction-and-Inhibition-of-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1977,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0520371","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,4,1]]}}}