{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:02:38Z","timestamp":1778533358454,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,5,1]]},"abstract":"<jats:p>1. A radioimmunoassay for the measurement of angiotensin II in 1 ml of plasma has been developed and used to measure angiotensin II in maternal peripheral, cord venous and cord arterial blood in 45 patients at delivery.<\/jats:p>\n               <jats:p>2. In babies delivered vaginally, cord venous and cord arterial concentrations of angiotensin II were significantly higher than maternal venous blood concentrations. There was a significant relationship between both cord venous and cord arterial concentrations and maternal concentrations of angiotensin II.<\/jats:p>\n               <jats:p>3. Cord venous concentrations of angiotensin II were significantly greater than those in cord arterial blood in babies delivered vaginally but not in those delivered by lower-segment Caesarean section. This suggests the possibility that, during labour, the placenta may contribute to foetal concentrations of angiotensin II.<\/jats:p>\n               <jats:p>4. Maternal and cord venous concentrations of angiotensin II were significantly higher in patients with hypertensive disease of pregnancy than in those who had remained normotensive throughout pregnancy.<\/jats:p>\n               <jats:p>5. Cord venous concentrations of angiotensin II increased significantly with increasing duration of the second stage of labour.<\/jats:p>","DOI":"10.1042\/cs0520449","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:32:03Z","timestamp":1438943523000},"page":"449-456","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Factors affecting angiotensin II concentrations in the human infant at birth"],"prefix":"10.1042","volume":"52","author":[{"given":"Fiona Broughton","family":"Pipkin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nottingham University Medical School, Nottingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Symonds","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Nottingham University Medical School, Nottingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/5\/449\/739429\/cs0520449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/52\/5\/449\/739429\/cs0520449.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T16:36:38Z","timestamp":1571934998000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/52\/5\/449\/70809\/Factors-affecting-angiotensin-II-concentrations-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1977,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0520449","relation":{},"ISSN":["0301-0538"],"issn-type":[{"value":"0301-0538","type":"print"}],"subject":[],"published":{"date-parts":[[1977,5,1]]}}}